Gantrisin Side Effects

Generic Name: sulfisoxazole

Please note - some side effects for Gantrisin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Gantrisin - for the Consumer

Gantrisin Suspension

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Gantrisin Suspension:

Dizziness; drowsiness; headache; gas; loss of appetite; nausea; sensitivity to sunlight; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; bluish color of skin; dark urine or decreased amount of urine; fainting; fast heartbeat; hallucinations; joint pain; mouth sores or irritation; pale skin; persistent sore throat or fever; pounding in the chest; red or purple patches under the skin; red, blistered, or swollen skin; seizures; severe or persistent diarrhea; severe reaction to the sun; stomach pain or cramps; trouble urinating; unusual tiredness or weakness; vaginal irritation or discharge; yellowing of the eyes or skin.

Gantrisin Side Effects - for the Professional

Gantrisin

The listing that follows includes adverse reactions both that have been reported with Gantrisin and some which have not been reported with this specific drug; however, the pharmacologic similarities among the sulfonamides require that each of the reactions be considered with the administration of Gantrisin.

Allergic/Dermatologic: Anaphylaxis, erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis, exfoliative dermatitis, angioedema, arteritis and vasculitis, allergic myocarditis, serum sickness, rash, urticaria, pruritus, photosensitivity, and conjunctival and scleral injection, generalized allergic reactions and generalized skin eruptions. In addition, periarteritis nodosa and systemic lupus erythematosus have been reported.

Cardiovascular: Tachycardia, palpitations, syncope, cyanosis.

Endocrine: The sulfonamides bear certain chemical similarities to some goitrogens, diuretics (acetazolamide and thiazides) and oral hypoglycemia agents. Cross-sensitivity may exist with these agents. Development of goiter, diuresis and hypoglycemia have occurred rarely in patients receiving sulfonamides.

Gastrointestinal: Hepatitis, hepatocellular necrosis, jaundice, pseudomembranous colitis, nausea, emesis, anorexia, abdominal pain, diarrhea, gastrointestinal hemorrhage, melena, flatulence, glossitis, stomatitis, salivary gland enlargement, pancreatitis.

Onset of pseudomembranous colitis symptoms may occur during or after treatment with sulfisoxazole.

Sulfisoxazole has been reported to cause increased elevations of liver-associated enzymes in patients with hepatitis.

Genitourinary: Crystalluria, hematuria, BUN and creatinine elevations, nephritis and toxic nephrosis with oliguria and anuria. Acute renal failure and urinary retention have also been reported. The frequency of renal complications, commonly associated with some sulfonamides, is lower in patients receiving the more soluble sulfonamides such as sulfisoxazole.

Hematologic: Leukopenia, agranulocytosis, aplastic anemia, thrombocytopenia, purpura, hemolyticanemia, anemia, eosinophilia, clotting disorders including hypoprothrombinemia, and hypofibrinogenemia, sulfhemoglobinemia, methemoglobinemia.

Musculoskeletal: Arthralgia, myalgia.

Neurologic: Headache, dizziness, peripheral neuritis, paresthesia, convulsions, tinnitus, vertigo, ataxia, intracranial hypertension.

Psychiatric: Psychosis, hallucination, disorientation, depression, anxiety, apathy.

Respiratory: Cough, shortness of breath, pulmonary infiltrates.

Vascular: Angioedema, arteritis, vasculitis.

Miscellaneous: Edema (including periorbital), pyrexia, drowsiness, weakness, fatigue, lassitude, rigors, flushing, hearing loss, insomnia, pneumonitis, chills.

Side Effects by Body System

General

In general, although not every side effect listed in the side effects section may have been reported with the use of sulfisoxazole, they have all been reported with the use of one or more sulfonamide compounds.

Sulfisoxazole was generally well tolerated. Less than 0.1% of patients experienced serious side effects from sulfisoxazole.

Hypersensitivity

Hypersensitivity side effects have included anaphylaxis, erythema multiforme (Stevens-Johnson syndrome), toxic epidermal necrolysis, angioedema, arteritis and vasculitis, serum sickness, conjunctival and scleral injection, generalized allergic reactions, and allergic myocarditis.

The use of sulfonamide antibiotics is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis, although these phenomena are rare as a whole.

Dermatologic

Dermatologic side effects have included exfoliative dermatitis, rash, pruritus, photosensitivity, periarteritis nodosa, systemic lupus erythematosus, and generalized skin eruptions.

Hematologic

Hematologic side effects have included agranulocytosis, leukopenia, thrombocytopenia, aplastic anemia, purpura, hemolytic anemia, eosinophilia, clotting disorders including hypoprothrombinemia, hypofibrinogenemia, sulfhemoglobinemia, and methemoglobinemia.

Hepatic

Hepatic side effects have included hepatitis, hepatocellular necrosis, and jaundice. Elevated liver-associated enzymes have been reported in patients with hepatitis. Rare cases of hepatic necrosis have been associated with some sulfonamides.

Renal

Renal side effects have included elevated BUN and creatinine, acute renal failure, nephritis, and nephrosis with oliguria and anuria. The frequency of renal complications is lower with the more soluble sulfonamides, such as sulfisoxazole.

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