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Flonase Side Effects

Generic Name: fluticasone nasal

Note: This page contains information about the side effects of fluticasone nasal. Some of the dosage forms included on this document may not apply to the brand name Flonase.

Not all side effects for Flonase may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to fluticasone nasal: nasal spray

In addition to its needed effects, some unwanted effects may be caused by fluticasone nasal (the active ingredient contained in Flonase). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking fluticasone nasal, check with your doctor or nurse as soon as possible:

More common
  • Bloody mucus or unexplained nosebleeds
  • cough
  • headache
  • nausea
  • shortness of breath
  • vomiting
Less common
  • Diarrhea
  • dizziness
  • excessive mucus
  • fever
  • general aches and pains
  • loss of appetite
  • stomach pain
  • weakness
  • runny nose
  • White patches inside nose or throat
Symptoms of overdose
  • Blindness
  • blurred vision
  • bone fractures
  • excess facial hair growth in females
  • fullness of face, neck, and trunk
  • high blood pressure
  • impotence in males
  • increased thirst or urination
  • lack of menstrual periods
  • muscle wasting
  • weakness

Some of the side effects that can occur with fluticasone nasal may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Burning, dryness, or other irritation inside the nose
  • sore throat
Less common
  • Runny nose

For Healthcare Professionals

Applies to fluticasone nasal: nasal spray


Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis effects (including growth reduction)[Ref]

Nervous system

Common (1% to 10%): Headache, unpleasant taste, unpleasant smell[Ref]


Common (1% to 10%): Toothache, nausea, diarrhea, abdominal distension, vomiting, gastrointestinal gaseous symptoms
Frequency not reported: Gum signs and symptoms[Ref]


Very rare (less than 0.01%): Hypersensitivity reactions (including anaphylaxis, angioedema, rash, urticaria, bronchospasm)[Ref]


Common (1% to 10%): Conjunctivitis
Very rare (less than 0.01%): Cataracts, glaucoma, raised intraocular pressure
Frequency not reported: Transient ocular changes[Ref]


Frequency not reported: Candida albicans infection, immunosuppression[Ref]


Very common (10% or more): Nasopharyngitis (26%), epistaxis (20%)
Common (1% to 10%): Pharyngolaryngeal pain, nasal ulceration, cough, pharyngitis, bronchitis, nasal dryness, throat irritation, throat dryness, blood in nasal mucosa, nasal irritation
Uncommon (0.1% to 1%): Rhinalgia, nasal discomfort (including nasal burning, nasal soreness)
Postmarketing reports: Nasal septal perforation[Ref]


The most commonly reported side effects were nasopharyngitis, epistaxis, and pyrexia.[Ref]


Common (1% to 10%): Back pain[Ref]


Very common (10% or more): Pyrexia
Frequency not reported: Impaired wound healing[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Flonase (fluticasone)." Glaxo Wellcome, Research Triangle Park, NC.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.