Ferumoxytol Side Effects

Not all side effects for ferumoxytol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ferumoxytol: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by ferumoxytol. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ferumoxytol, check with your doctor or nurse immediately:

Less common
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chest pain
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • rapid weight gain
  • shortness of breath
  • sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wheezing
Incidence not known
  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • chest discomfort
  • cough
  • decreased urine output
  • difficulty with swallowing
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • irregular breathing
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of consciousness
  • nausea or vomiting
  • no blood pressure or pulse
  • pain in the shoulders, arms, jaw, or neck
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • stopping of the heart
  • swelling of the face, fingers, feet, or lower legs
  • troubled breathing
  • unconsciousness
  • unresponsiveness
  • weight gain

Some of the side effects that can occur with ferumoxytol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Abdominal or stomach pain
  • back pain
  • headache
  • muscle spasms

For Healthcare Professionals

Applies to ferumoxytol: intravenous solution

Cardiovascular

Cardiovascular side effects have included hypotension (2.5%), chest pain (1.3%), and hypertension (1%). Anaphylactic type reactions presenting with cardiac/cardiorespiratory arrest, clinically significant hypotension, syncope, unresponsiveness, loss of consciousness, tachycardia/rhythm abnormalities, angioedema, ischemic myocardial events, congestive heart failure, pulse absent, and cyanosis have been reported postmarketing.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea (4%), nausea (3.1%), constipation (2.1%), vomiting (1.5%), and abdominal pain (1.3%).[Ref]

Nervous system

Nervous system side effects have included dizziness (2.6%), headache (1.8%), and pyrexia (1%).[Ref]

Respiratory

Respiratory side effects have included cough (1.3%) and dyspnea (1%).[Ref]

Dermatologic

Dermatologic side effects have included pruritus (1.2%) and rash (1%).[Ref]

Musculoskeletal

Musculoskeletal side effects have included back pain (1%) and muscle spasms (1%).[Ref]

Metabolic

Metabolic side effects have included peripheral edema (2%) and edema (1.5%).[Ref]

Hypersensitivity

Hypersensitivity reactions have included anaphylaxis and/or anaphylactoid reactions. Anaphylactic type reactions presenting with cardiac/cardiorespiratory arrest, clinically significant hypotension, syncope, and unresponsiveness have been reported in the postmarketing experience.

References

1. "Product Information. Feraheme (ferumoxytol)." Alza Pharmaceuticals, Mountain View, CA.

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