Ergotamine Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 21, 2023.
Applies to ergotamine: oral tablets, rectal suppositories, sublingual tablets.
Warning
Side effects include:
Nausea, vomiting, abdominal pain, numbness and tingling of the fingers and toes, muscle pain in the extremities, weakness in the legs.
For Healthcare Professionals
Applies to ergotamine: compounding powder, sublingual tablet.
General
The most commonly reported adverse effects have included nausea and vomiting.[Ref]
Cardiovascular
Serious vasoconstrictive have occurred, more commonly with long-term therapy at relatively high doses, however, they have been reported with short-term or normal doses.
Nervous system
Reports of cerebral ischemia, including 1 death, have been reported for patients receiving ergotamine and protease inhibitors concomitantly. A black box warning is now required labeling for these drugs.
Cardiovascular
Frequency not reported: Ischemia, cyanosis, absence of pulse, cold extremities, precordial distress, EKG changes, gangrene, transient tachycardia, bradycardia, hypertension
Nervous system
Rare (less than 0.1%): Cerebral ischemia
Frequency not reported: Paresthesias, numbness, weakness
Gastrointestinal
Frequency not reported: Nausea, vomiting
Musculoskeletal
Frequency not reported: Musculoskeletal aches, pains, and cramps
Other
Frequency not reported: Vertigo
Hypersensitivity
Frequency not reported: Localized edema, itching
More about ergotamine
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References
1. Product Information. Ergomar (ergotamine). Rosedale Therapeutics. 2013.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.