Medication Guide App

Edarbyclor Side Effects

Generic Name: azilsartan medoxomil / chlorthalidone

Note: This page contains information about the side effects of azilsartan medoxomil / chlorthalidone. Some of the dosage forms included on this document may not apply to the brand name Edarbyclor.

Not all side effects for Edarbyclor may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to azilsartan medoxomil / chlorthalidone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by azilsartan medoxomil / chlorthalidone. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking azilsartan medoxomil / chlorthalidone:

Less common
  • Blurred vision
  • confusion
  • convulsions
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • sweating
  • unusual tiredness or weakness
Incidence not known
  • Ankle, knee, or great toe joint pain
  • joint stiffness or swelling
  • lower back, side, or stomach pain
  • swelling of the feet or lower legs

Some of the side effects that can occur with azilsartan medoxomil / chlorthalidone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Dizziness
  • Cough
  • diarrhea
  • lack or loss of strength
  • muscle spasm
Incidence not known
  • Headache
  • loss of appetite
  • rash
  • stomach cramps

For Healthcare Professionals

Applies to azilsartan medoxomil / chlorthalidone: oral tablet


Cardiovascular side effects have included hypotension (1.7%).[Ref]


Dermatologic side effects have included rash.[Ref]


Endocrine side effects have included increased uric acid and increased cholesterol.[Ref]


Gastrointestinal side effects have included vomiting, diarrhea, and GI upset.[Ref]


Hematologic side effects have included azotemia, increased serum creatinine, and increased blood urea nitrogen (BUN).[Ref]


Musculoskeletal side effects have included asthenia and muscle spasm.[Ref]

Nervous system

Nervous system side effects have included dizziness (8.9%), postural dizziness, fatigue (2%), headache, and syncope (0.3%).[Ref]


Respiratory side effects have included cough.[Ref]


1. "Product Information. Edarbyclor (azilsartan-chlorthalidone)." Takeda Pharmaceuticals America, Lincolnshire, IL.

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