Diphenhydramine / phenylephrine Side Effects
Some side effects of diphenhydramine / phenylephrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to diphenhydramine / phenylephrine: tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking diphenhydramine / phenylephrine:
Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability (especially in children); headache; loss of appetite; nausea; nervousness; restlessness; trouble sleeping; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased coordination; difficulty urinating; fast or irregular heartbeat; fever; hallucinations; seizure; severe dizziness or drowsiness; severe nervousness, anxiety, restlessness, or trouble sleeping; tremors; unusual weakness.
For Healthcare Professionals
Applies to diphenhydramine / phenylephrine: oral disintegrating strip, oral liquid, oral suspension extended release, oral tablet chewable extended release
Cardiovascular side effects have included hypotension, palpitations, tachycardia, and extrasystole.
Hematologic side effects have included hemolytic anemia, agranulocytosis, and thrombocytopenia.
Nervous system side effects have included sleepiness, sedation, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, paresthesia, headache, vertigo, tinnitus, acute labyrinthitis, neuritis, and convulsions.
Ocular side effects have included blurred vision and diplopia.
Gastrointestinal side effects have included epigastric distress, anorexia, nausea, vomiting, diarrhea, and constipation.
Genitourinary side effects have included urinary frequency, difficult urination, urinary retention, and early menses.
Hypersensitivity side effects have included urticaria, drug rash, anaphylactic shock, and photosensitivity.
General side effects have included chills, excessive perspiration, and dryness of nose, throat and mouth.
More about diphenhydramine/phenylephrine
- Diphenhydramine/phenylephrine chewable tablets
- Diphenhydramine/phenylephrine liquid
- Diphenhydramine/phenylephrine strips
- Diphenhydramine/phenylephrine suspension
- Diphenhydramine and phenylephrine
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