Diphenhydramine / Phenylephrine Dosage

This dosage information may not include all the information needed to use Diphenhydramine / Phenylephrine safely and effectively. See additional information for Diphenhydramine / Phenylephrine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Allergic Rhinitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Adult Dose for Cold Symptoms

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Adult Dose for Sinusitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release:
5 to 10 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours

Usual Pediatric Dose for Allergic Rhinitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Usual Pediatric Dose for Cold Symptoms

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Usual Pediatric Dose for Sinusitis

diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet:
diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release:
13 yrs or older: 1 to 2 tablets orally every 12 hours
6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension:
13 yrs or older: 5 to 10 mL orally every 12 hours
6 to 12 yrs: 2.5 to 5 mL orally every 12 hours
2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours

diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release:
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours.

diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid:
12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours
6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours

diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid:
12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours
6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid:
6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours

diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip:
6 to 11 yrs: dissolve 1 strip on tongue

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Watch this video series to learn about managing severe allergies (anaphylaxis).

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