Difluprednate ophthalmic Side Effects

Not all side effects for difluprednate ophthalmic may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to difluprednate ophthalmic: ophthalmic emulsion

Along with its needed effects, difluprednate ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking difluprednate ophthalmic:

More common
  • Blurred vision
  • change in color vision
  • decreased vision or other changes in vision
  • difficulty seeing at night
  • eye discomfort
  • eye pain
  • eye redness
  • increase in blood flow to the whites of the eyes
  • increased sensitivity of the eyes to sunlight
  • painful irritation of the front clear part of the eye
  • sensitivity of the eyes to light
  • swelling or redness of the eye and lining of the eyelid
Less common
  • Eyelid irritation and crusting
  • tearing
  • throbbing eye pain
  • watering of the eyes

Some side effects of difluprednate ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Dry eyes
Rare
  • Burning, itching, or soreness of the eye
  • feeling of having something in the eye

For Healthcare Professionals

Applies to difluprednate ophthalmic: ophthalmic emulsion

Ocular

Ocular side effects have included elevated intraocular pressure, which may be associated with optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the cornea or sclera. Other side effects have included corneal edema, ciliary and conjunctival hyperemia, eye pain, photophobia, posterior capsule opacification, anterior chamber cells, anterior chamber flare, conjunctival edema, and blepharitis. Other ocular side effects occurring in 1 to 5% of subjects included reduced visual acuity, punctate keratitis, eye inflammation, and iritis. Ocular side effects occurring in less then 1% of subjects included application site discomfort or irritation, corneal pigmentation and striae, episcleritis, eye pruritis, eyelid irritation and crusting, foreign body sensation, increased lacrimation, macular edema, scleral hyperemia, and uveitis. Most of these events may have been the consequence of the surgical procedure.

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