Cyramza Side Effects

Generic Name: ramucirumab

Note: This page contains information about the side effects of ramucirumab. Some of the dosage forms included on this document may not apply to the brand name Cyramza.

Not all side effects for Cyramza may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ramucirumab: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by ramucirumab (the active ingredient contained in Cyramza). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ramucirumab, check with your doctor or nurse immediately:

More common
  • Back pain or spasms
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • coma
  • confusion
  • convulsions
  • decreased urine output
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of warmth
  • feeling unusually cold
  • headache
  • increased thirst
  • muscle pain or cramps
  • nausea or vomiting
  • nervousness
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • sweating
  • swelling of the face, ankles, or hands
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness
Less common
  • Abdominal or stomach pain
  • bleeding gums
  • bloody nose
  • cough
  • coughing up blood
  • difficulty with breathing or swallowing
  • dizziness
  • fever
  • inability to speak
  • increased menstrual flow or vaginal bleeding
  • lower back or side pain
  • no blood pressure or pulse
  • nosebleeds
  • pain or discomfort in the arms, jaw, back, or neck
  • painful or difficult urination
  • pain in the chest, groin, or legs, especially calves of the legs
  • pale skin
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • severe constipation
  • severe headaches of sudden onset
  • severe numbness, especially on one side of the face or body
  • severe or sudden headache
  • slurred speech
  • sore throat
  • stopping of heart
  • sudden loss of coordination
  • sudden onset of shortness of breath for no apparent reason
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • temporary blindness
  • ulcers, sores, or white spots in the mouth
  • unconsciousness
  • unusual bleeding or bruising
Rare
  • Heartburn
  • indigestion
  • severe abdominal or stomach pain, cramping, or burning
  • vomiting of material that looks like coffee grounds, severe and continuing

Some of the side effects that can occur with ramucirumab may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea

For Healthcare Professionals

Applies to ramucirumab: intravenous solution

General

The most common side effects reported were hypertension and diarrhea.

Gastrointestinal

Very common (10% or more): Diarrhea (14%)
Common (1% to 10%): Intestinal obstruction
Uncommon (0.1% to 1%): Gastrointestinal perforation

Immunologic

Common (1% to 10%): Anti-ramucirumab (the active ingredient contained in Cyramza) antibodies
Uncommon (0.1% to 1%): Infusion related reactions

Cardiovascular

Very common (10% or more): Hypertension (16%)
Common (1% to 10%): Arterial thromboembolic events

Dermatologic

Common (1% to 10%): Rash

Hematologic

Common (1% to 10%): Anemia, neutropenia, epistaxis

Metabolic

Common (1% to 10%): Hyponatremia

Nervous system

Common (1% to 10%): Headache
Rare (less than 0.1%): Reversible Posterior Leukoencephalopathy Syndrome (RPLS)

Renal

Common (1% to 10%): Proteinuria

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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