Cortisone Side Effects

Not all side effects for cortisone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cortisone: oral tablets

Side effects include:

Associated with long-term therapy: bone loss, cataracts, indigestion, muscle weakness, back pain, bruising, oral candidiasis. (See Warnings/Precautions under Cautions.)

For Healthcare Professionals

Applies to cortisone: compounding powder, injectable suspension, oral tablet

Cardiovascular

Cardiovascular side effects including myocardial rupture following recent myocardial infarction, fluid retention, sodium retention, congestive heart failure, potassium loss, hypokalemic alkalosis, and hypertension have been reported with cortisone therapy.

Gastrointestinal

Gastrointestinal side effects including peptic ulcer with potential perforation and hemorrhage, perforation of small and large bowel, pancreatitis, abdominal distention, nausea, increased appetite, and ulcerative esophagitis have been reported.

Musculoskeletal

Musculoskeletal side effects including muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humoral heads, pathologic fracture of long bones, and tendon rupture have been reported.

Psychiatric

Psychiatric side effects including euphoria, insomnia, mood swings, personality changes, severe depression, and psychotic manifestations have been reported.

Nervous system

Nervous system side effects including convulsions, increased intracranial pressure with papilledema, vertigo, myalgia, arthralgia, malaise, headache, and psychic disturbances have been reported.

Endocrine

Endocrine side effects including development of cushingoid state, suppression of growth in children, and secondary adrenocortical and pituitary unresponsiveness have been reported.

Ocular

Ocular side effects including posterior subcapsular cataracts, increased intraocular pressure, glaucoma, and exophthalmos have been reported.

Hematologic

Thromboembolism has rarely been reported.

Genitourinary

Increase/decrease in motility and number of spermatozoa in men and menstrual irregularities in women have been reported rarely.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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