Clotrimazole topical Side Effects

Not all side effects for clotrimazole topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to clotrimazole topical: topical cream, topical lotion, topical solution

In addition to its needed effects, some unwanted effects may be caused by clotrimazole topical. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking clotrimazole topical, check with your doctor or nurse as soon as possible:

  • Skin rash, hives, blistering, burning, itching, peeling, redness, stinging, swelling, or other sign of skin irritation not present before use of this medicine

For Healthcare Professionals

Applies to clotrimazole topical: compounding powder, topical cream, topical lotion, topical powder, topical solution, topical spray, vaginal cream with applicator, vaginal kit, vaginal tablet

Dermatologic

Dermatologic side effects have included erythema, stinging, blistering, peeling, edema, itching, burning, and general skin irritation. Contact dermatitis, confirmed by patch testing, has been documented.[Ref]

Genitourinary

Genitourinary system effects associated with intravaginal use have included burning, itching, cramping, pain, and bleeding. Vulvar lesions and rash have rarely been reported.[Ref]

References

1. "Product Information. Mycelex (clotrimazole)." Bayer, West Haven, CT.

2. Kalb RE, Grossman ME "Contact dermatitis to clotrimazole." Cutis 36 (1985): 240-2

3. Roller JA "Contact allergy to clotrimazole." Br Med J 2 (1978): 737

4. Baes H "Contact dermatitis from clotrimazole." Contact Dermatitis 32 (1995): 187-8

5. Balato N, Lembo G, Nappa P, Ayala F "Contact dermatitis from clotrimazole." Contact Dermatitis 12 (1985): 110

6. Lebherz TB, Ford LC, Kleinkopf V "A comparison of a three-day and seven-day clotrimazole regimen for vulvovaginal candidiasis." Clin Ther 3 (1981): 344-8

7. Stein GE, Christensen S, Mummaw N "Comparative study of fluconazole and clotrimazole in the treatment of vulvovaginal candidiasis." DICP 25 (1991): 582-5

8. Lebherz T, Guess E, Wolfson N "Efficacy of single- versus multiple-dose clotrimazole therapy in the management of vulvovaginal candidiasis." Am J Obstet Gynecol 152 (1985): 965-8

9. Pons V, Greenspan D, Debruin M "Therapy for oropharyngeal candidiasis in HIV-infected patients: a randomized, prospective multicenter study of oral fluconazole versus clotrimazole troches. The Multicenter Study Group." J Acquir Immune Defic Syndr 6 (1993): 1311-6

10. Wolfson N, Riley J, Samuels B, Singh JM "Clinical toxicology of clotrimazole when administered vaginally." Clin Toxicol 18 (1981): 41-5

11. Brown D Jr, Binder GL, Gardner HL, Wells J "Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis." Obstet Gynecol 56 (1980): 121-3

12. Sawyer PR, Brogden RN, Pinder RM, Speight TM, Avery "Clotrimazole: a review of its antifungal activity and therapeutic efficacy." Drugs 9 (1975): 424-47

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