Cefizox Side Effects

Generic Name: ceftizoxime

Note: This page contains information about the side effects of ceftizoxime. Some of the dosage forms included on this document may not apply to the brand name Cefizox.

Not all side effects for Cefizox may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ceftizoxime: injectable powder for injection, intravenous solution

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody;

  • severe pain, burning, irritation, or skin changes where the needle was placed;

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

  • uneven heartbeats;

  • fever, chills, body aches, flu symptoms;

  • easy bruising or bleeding, unusual weakness;

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

  • seizure (black-out or convulsions); or

  • jaundice (yellowing of the eyes or skin).

Less serious side effects are more likely to occur, such as:

  • pain, irritation, or hardening where the injection was given;

  • stomach pain, nausea, vomiting;

  • numbness or tingling;

  • headache; or

  • vaginal itching or discharge.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

For Healthcare Professionals

Applies to ceftizoxime: injectable powder for injection, intravenous solution

General

Adverse effects may be more likely or more severe in patients with renal and/or liver dysfunction.[Ref]

Ceftizoxime is generally well-tolerated.[Ref]

Hypersensitivity

A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.[Ref]

Hypersensitivity reactions including rash, pruritus, and fever have been reported in 1% to 5% of patients. Numbness and anaphylaxis have been reported in less than 1% of patients. Cephalosporin class antibiotics have been associated with anaphylaxis, Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis.[Ref]

Gastrointestinal

Gastrointestinal side effects have included diarrhea, nausea, and vomiting in less than 1% of patients. Pseudomembranous colitis has been reported in patients treated with cephalosporins. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.[Ref]

Hematologic

Hematologic side effects have included transient eosinophilia, thrombocytosis, and positive Coombs' test in 1% to 5% of patients. Anemia, including occasionally fatal hemolytic anemia, leukopenia, neutropenia, and thrombocytopenia have been reported in less than 1% of patients. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, prolonged prothrombin time, hemorrhage, neutropenia, pancytopenia, and agranulocytosis.[Ref]

Renal

Renal side effects have included transient elevations of BUN and creatinine (less than 1%). Interstitial nephritis has been reported with some cephalosporins, and presents as reversible fever, azotemia, pyuria, and eosinophiluria. Cephalosporins as a class have been associated with renal dysfunction and toxic nephropathy.[Ref]

Hepatic

Hepatic side effects have included transient elevation of AST, ALT, and alkaline phosphatase in 1% to 5% of patients, and bilirubin increases in less than 1%. Cephalosporins as a class have been associated with hepatic dysfunction including cholestasis.[Ref]

Nervous system

Nervous system side effects including seizures have been associated with some cephalosporins in renally impaired patients.[Ref]

Local

Local side effects have included burning, cellulitis, phlebitis, pain, induration, tenderness, and paresthesia at the injection site in 1% to 5% of patients.[Ref]

Genitourinary

Genitourinary side effects have included vaginitis (less than 1%).[Ref]

References

1. "Product Information. Cefizox (ceftizoxime)." Fujisawa, Deerfield, IL.

2. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226

3. Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sanchez F, Perez E, Venuti A, Blanca M "Immediate allergic reactions to cephalosporins: Cross-reactivity and selective responses." J Allerg Clin Immunol 106 (2000): 1177-83

4. Neu HC "Ceftizoxime: a beta-lactamase-stable, broad-spectrum cephalosporin." Pharmacotherapy 4 (1984): 47-60

5. Tripi M, Pavone-Macaluso M, Giammanco A, Carella G "Randomized comparative trial with ceftizoxime and cefotaxime in urinary tract infections." Int Urol Nephrol 17 (1985): 195-202

6. Toll LL, Lee M, Sharifi R "Cefoxitin-induced interstitial nephritis." South Med J 80 (1987): 274-5

7. Haskell RJ, Fujita NK, Stevenson JA, Border WA "Cefoxitin-induced interstitial nephritis." Arch Intern Med 141 (1981): 1557

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