Ceftizoxime use while Breastfeeding

Drugs containing Ceftizoxime: Cefizox

Ceftizoxime Levels and Effects while Breastfeeding

Summary of Use during Lactation

Ceftizoxime is acceptable to use during breastfeeding. Limited information indicates that single maternal doses of ceftizoxime up to 1 gram produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. After a single 1 gram intravenous dose of ceftizoxime in 2 women, milk levels ranged from 0.31 to 0.43 mg/L from 2 to 8 hours after the dose. The peak milk level occurred at 2 hours after the dose in one and 6 hours after the dose in the other.[1]

Five women were given 1 gram of ceftizoxime intravenously. Average peak milk levels of 0.39 mg/L occurred 3 hours after the dose, although individuals had peak levels ranging from 0.31 mg/L at 3 hours after the dose to 0.83 mg/L at 6 hours after the dose. Four of the women had undetectable milk levels by 6 hours after the dose.[2]

In six women given 1 gram of ceftizoxime intravenously, average milk levels were 0.25 mg/L 1 hour after the dose.[3]

After a single 1 gram intravenous dose in 2 women, ceftizoxime milk levels were measurable only 4 hours after the dose and averaged 0.1 mg/L.[4]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Motomura R, Kohno M, Mori H et al. Basic and clinical studies of ceftizoxime in obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28(suppl 5):888-99.

2. Takase Z, Inoue K, Shirafuji H et al. Clinical and laboratory studies on ceftizoxime (CZX) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1980;28 (Suppl 5):863-73.

3. Gerding DN, Peterson LR. Comparative tissue and extravascular fluid concentrations of ceftizoxime. J Antimicrob Chemother. 1982;10(suppl C):105-16. PMID: 6295995

4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy. 1984;5:57-60. PMID: 6743732

Ceftizoxime Identification

Substance Name

Ceftizoxime

CAS Registry Number

68401-81-0

Drug Class

• Antiinfective Agents
• Antibacterial Agents
• Cephalosporins

Administrative Information

LactMed Record Number

56

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2012-03-01

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

• Ceftizoxime use during Pregnancy
• Ceftizoxime Consumer Information
• Breastfeeding Support Group
• Safe Medications during Breastfeeding
• Medicine use while Breastfeeding
• Medicine use during Pregnancy

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.