Caprelsa Side Effects

Generic Name: vandetanib

Note: This page contains information about the side effects of vandetanib. Some of the dosage forms included on this document may not apply to the brand name Caprelsa.

Not all side effects for Caprelsa may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to vandetanib: oral tablet

In addition to its needed effects, some unwanted effects may be caused by vandetanib (the active ingredient contained in Caprelsa). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking vandetanib:

More common
  • Abdominal or stomach cramps or pain
  • bleeding gums
  • blurred vision
  • body aches or pain
  • chest pain
  • cloudy urine
  • confusion
  • convulsions
  • cough
  • coughing up blood
  • difficulty with breathing or swallowing
  • dizziness
  • ear congestion
  • fainting
  • fever or chills
  • headache
  • increased menstrual flow or vaginal bleeding
  • irregular heartbeat recurrent
  • loss of voice
  • muscle cramps in the hands, arms, feet, legs, or face
  • nervousness
  • nosebleeds
  • numbness and tingling around the mouth, fingertips, or feet
  • paralysis
  • pounding in the ears
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stuffy or runny nose
  • tenderness
  • tightness in the chest
  • tremor
  • troubled breathing
  • unusual tiredness or weakness (severe)
  • watery or bloody diarrhea
Less common
  • Blue lips, fingernails, or skin
  • chest pain or discomfort
  • dilated neck veins
  • extreme fatigue
  • foreign substance into the lungs
  • infection from breathing
  • irregular breathing
  • irregular heartbeat
  • irregular, fast or slow, or shallow breathing
  • lightheadedness
  • no breathing
  • swelling of the face, fingers, feet, or lower legs
  • weight gain
  • Bloating
  • constipation
  • darkened urine
  • decreased urine output
  • indigestion
  • loss of appetite
  • nausea
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • yellow eyes or skin

Some of the side effects that can occur with vandetanib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Acid or sour stomach
  • belching
  • blemishes on the skin
  • blindness
  • blistering, crusting, irritation, itching, or reddening of the skin
  • change in taste
  • cracked, dry, or scaly skin
  • cracks in the skin
  • decreased appetite
  • decreased vision
  • decreased weight
  • depression
  • discoloration of the fingernails or toenails
  • dry mouth
  • dry skin
  • hair loss or thinning of the hair
  • heartburn
  • increased sensitivity of the skin to sunlight
  • itching skin
  • lack or loss of strength
  • loosening of the fingernails
  • loss of heat from the body
  • loss of taste
  • muscle aches or spasms
  • pimples
  • rash with flat lesions or small raised lesions on the skin
  • red, swollen skin
  • redness or other discoloration of the skin
  • redness or soreness around the fingernails
  • severe sunburn
  • stomach discomfort or upset
  • swelling
  • trouble sleeping

For Healthcare Professionals

Applies to vandetanib: oral tablet


In general, the most commonly reported side effects (greater than 20%) have included diarrhea, rash, acne, nausea, hypertension, headache, fatigue, decreased appetite, abdominal pain, hypocalcemia, hypoglycemia, and increased ALT.


Cardiovascular side effects have included hypertension (33%; grade 3 to 4: 9%), QT interval prolongation (14%; grade 3 to 4: 8%), cardiac failure, and arrhythmias.


The types of rash reported have included erythematous rash, generalized rash, maculopapular rash, exfoliative dermatitis, bullous dermatitis, generalized erythema, and eczema.

Nail abnormalities include nail disorder, nail bed inflammation, nail bed tenderness, paronychia, nail bed infection, and nail infection.

Dermatologic side effects have included rash (53%; grade 3 to 4: 5%), dermatitis acneiform/acne (35%; grade 3 to 4: 1%), dry skin (15%), photosensitivity reaction (13%; grade 3 to 4: 2%), pruritus (11%; grade 3 to 4: 1%), nail abnormalities (9%), alopecia (8%), folliculitis, blue-gray macules, and hand-foot skin reaction.


Gastrointestinal side effects have included diarrhea/colitis (57%; grade 3 to 4: 11%), nausea (33%; grade 3 to 4: 1%), decreased appetite (21%; grade 3 to 4: 4%), abdominal pain (21%; grade 3 to 4: 3%), vomiting (15%; grade 3 to 4: 1%), dyspepsia (11%), dry mouth (9%), intestinal perforation (0.4%), and pancreatitis.


Genitourinary side effects have included proteinuria (10%).


Hematologic side effects have included bleeding events, decreased white blood cells (19%), decreased hemoglobin (13%), decreased neutrophils (10%), and decreased platelets (9%).


Hepatic side effects have included increased ALT (51%).


Immunologic side effects have included sepsis.


Metabolic side effects have included decreased calcium (57%; grade 3 to 4: 6%), hypoglycemia (24%), weight loss (10%; grade 3 to 4: 1%), decreased magnesium (7%), increased calcium (7%), decreased potassium (6%), increased potassium (6%), increased glucose (5%), and increased magnesium (3%).


Musculoskeletal side effects have included arthralgia.

Nervous system

Nervous system side effects have included headache (26%; grade 3 to 4: 1%) and dysgeusia (8%).


Ocular side effects have included corneal abnormalities (13%) and blurred vision (9%).


Other side effects have included fatigue (24%; grade 3 to 4: 6%), asthenia, and pyrexia.


Psychiatric side effects have included depression (10%; grade 3 to 4: 2%).


Renal side effects have included increased creatinine (16%) and increased bilirubin (13%).


Respiratory side effects have included upper respiratory infection (23%), respiratory failure, respiratory arrest, and aspiration pneumonia.

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