Caprelsa Side Effects
Generic Name: vandetanib
Note: This document contains side effect information about vandetanib. Some of the dosage forms listed on this page may not apply to the brand name Caprelsa.
Some side effects of Caprelsa may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to vandetanib: oral tablet
Along with its needed effects, vandetanib (the active ingredient contained in Caprelsa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking vandetanib:More common
- Abdominal or stomach cramps or pain
- bleeding gums
- blurred vision
- body aches or pain
- chest pain
- cloudy urine
- coughing up blood
- difficulty with breathing or swallowing
- ear congestion
- fever or chills
- increased menstrual flow or vaginal bleeding
- irregular heartbeat recurrent
- loss of voice
- muscle cramps in the hands, arms, feet, legs, or face
- numbness and tingling around the mouth, fingertips, or feet
- pounding in the ears
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- slow or fast heartbeat
- sore throat
- stuffy or runny nose
- tightness in the chest
- troubled breathing
- unusual tiredness or weakness (severe)
- watery or bloody diarrhea
- Blue lips, fingernails, or skin
- chest pain or discomfort
- dilated neck veins
- extreme fatigue
- foreign substance into the lungs
- infection from breathing
- irregular breathing
- irregular heartbeat
- irregular, fast or slow, or shallow breathing
- no breathing
- swelling of the face, fingers, feet, or lower legs
- weight gain
- darkened urine
- decreased urine output
- loss of appetite
- pains in the stomach, side, or abdomen, possibly radiating to the back
- yellow eyes or skin
Some side effects of vandetanib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Acid or sour stomach
- blemishes on the skin
- blistering, crusting, irritation, itching, or reddening of the skin
- change in taste
- cracked, dry, or scaly skin
- cracks in the skin
- decreased appetite
- decreased vision
- decreased weight
- discoloration of the fingernails or toenails
- dry mouth
- dry skin
- hair loss or thinning of the hair
- increased sensitivity of the skin to sunlight
- itching skin
- lack or loss of strength
- loosening of the fingernails
- loss of heat from the body
- loss of taste
- muscle aches or spasms
- rash with flat lesions or small raised lesions on the skin
- red, swollen skin
- redness or other discoloration of the skin
- redness or soreness around the fingernails
- severe sunburn
- stomach discomfort or upset
- trouble sleeping
For Healthcare Professionals
Applies to vandetanib: oral tablet
In general, the most commonly reported side effects (greater than 20%) have included diarrhea, rash, acne, nausea, hypertension, headache, fatigue, decreased appetite, abdominal pain, hypocalcemia, hypoglycemia, and increased ALT.
Cardiovascular side effects have included hypertension (33%; grade 3 to 4: 9%), QT interval prolongation (14%; grade 3 to 4: 8%), cardiac failure, and arrhythmias.
The types of rash reported have included erythematous rash, generalized rash, maculopapular rash, exfoliative dermatitis, bullous dermatitis, generalized erythema, and eczema.
Nail abnormalities include nail disorder, nail bed inflammation, nail bed tenderness, paronychia, nail bed infection, and nail infection.
Dermatologic side effects have included rash (53%; grade 3 to 4: 5%), dermatitis acneiform/acne (35%; grade 3 to 4: 1%), dry skin (15%), photosensitivity reaction (13%; grade 3 to 4: 2%), pruritus (11%; grade 3 to 4: 1%), nail abnormalities (9%), alopecia (8%), folliculitis, blue-gray macules, and hand-foot skin reaction.
Gastrointestinal side effects have included diarrhea/colitis (57%; grade 3 to 4: 11%), nausea (33%; grade 3 to 4: 1%), decreased appetite (21%; grade 3 to 4: 4%), abdominal pain (21%; grade 3 to 4: 3%), vomiting (15%; grade 3 to 4: 1%), dyspepsia (11%), dry mouth (9%), intestinal perforation (0.4%), and pancreatitis.
Genitourinary side effects have included proteinuria (10%).
Hematologic side effects have included bleeding events, decreased white blood cells (19%), decreased hemoglobin (13%), decreased neutrophils (10%), and decreased platelets (9%).
Hepatic side effects have included increased ALT (51%).
Immunologic side effects have included sepsis.
Metabolic side effects have included decreased calcium (57%; grade 3 to 4: 6%), hypoglycemia (24%), weight loss (10%; grade 3 to 4: 1%), decreased magnesium (7%), increased calcium (7%), decreased potassium (6%), increased potassium (6%), increased glucose (5%), and increased magnesium (3%).
Musculoskeletal side effects have included arthralgia.
Nervous system side effects have included headache (26%; grade 3 to 4: 1%) and dysgeusia (8%).
Ocular side effects have included corneal abnormalities (13%) and blurred vision (9%).
Other side effects have included fatigue (24%; grade 3 to 4: 6%), asthenia, and pyrexia.
Psychiatric side effects have included depression (10%; grade 3 to 4: 2%).
Renal side effects have included increased creatinine (16%) and increased bilirubin (13%).
Respiratory side effects have included upper respiratory infection (23%), respiratory failure, respiratory arrest, and aspiration pneumonia.
More about Caprelsa (vandetanib)
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