Skip to Content

Calfactant Side Effects

Commonly reported side effects of calfactant include cyanosis, airway obstruction, and bradycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to calfactant: intratracheal suspension

Calfactant causes few side effects. There is a possibility that the baby will have breathing difficulties during the calfactant treatment, and these problems may require further treatment by health care professionals. Your baby will remain under constant supervision during treatment with calfactant.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to calfactant: intratracheal suspension


Cardiovascular side effects have included cyanosis (65%) and bradycardia (34%).[Ref]


Respiratory side effects have included airway obstruction (39%), requirement for manual ventilation (16%), and reintubation (3%).[Ref]


Other side effects have included reflux of surfactant into endotracheal tube (21%), intraventricular hemorrhage (IVH), and periventricular leukomalacia (PVL). The IVH and PVL were not associated with increased mortality.[Ref]


1. "Product Information. Infasurf (calfactant)." Forest Pharmaceuticals, St. Louis, MO.

Not all side effects for calfactant may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.