Calfactant Dosage

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Usual Pediatric Dose for:

Additional dosage information:

Usual Pediatric Dose for Respiratory Distress Syndrome

<72 hours of life: 3 mL/kg instilled intratracheally every 12 hours for a total of up to 3 doses. For prevention of respiratory distress syndrome in premature infants of <29 weeks gestational age, the first dose is preferably given within 30 minutes of birth. For rescue treatment, the first dose is given as soon as possible.
>72 hours of life: Safety and efficacy have not been established.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

The dose is administered in 2 portions of 1.5 mL/kg through a 5-French catheter inserted into the endotracheal tube. Administration is made while ventilation is continued over 20 to 30 breaths for each portion, with small bursts timed during the inspiratory cycles. The 2 aliquots are separated by a pause to evaluate respiratory status and reposition the infant.

Repeat doses of 3 mL/kg may be given if there is evidence of continuing respiratory distress (the infant is still intubated and requires at least 30% inspired oxygen to maintain a PaO2 <=80 torr, or RDS has been confirmed by X-ray in infants who had received a prevention dose). Ventilator settings may require adjustment for repeat doses.

Heart rate, transcutaneous O2 saturation, and ABGs should be closely monitored.

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