Bynfezia Pen Side Effects
Generic name: octreotide
Medically reviewed by Drugs.com. Last updated on Jul 11, 2023.
Note: This document contains side effect information about octreotide. Some dosage forms listed on this page may not apply to the brand name Bynfezia Pen.
Applies to octreotide: powder for suspension, solution. Other dosage forms:
Serious side effects of Bynfezia Pen
Along with its needed effects, octreotide (the active ingredient contained in Bynfezia Pen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking octreotide:
More common
- Constipation
- depressed mood
- diarrhea
- dizziness
- dry skin and hair
- fainting
- fast, slow, or irregular heartbeat
- feeling cold
- hair loss
- hoarseness or husky voice
- loss of appetite
- muscle cramps and stiffness
- nausea
- severe stomach pain with nausea and vomiting
- stomach pain
- unusual tiredness or weakness
- vomiting
- weight gain
Less common
- Anxiety
- bladder pain
- bloody or cloudy urine
- blurred vision
- chills
- cold sweats
- collection of blood under the skin
- confusion
- cool, pale skin
- deep, dark purple bruise
- difficult, burning, or painful urination
- dry mouth
- flushed, dry skin
- frequent urge to urinate
- fruit-like breath odor
- headache
- increased hunger
- increased thirst
- increased urination
- itching, pain, redness, or swelling
- loss of consciousness
- lower back or side pain
- nervousness
- nightmares
- seizures
- shakiness
- slurred speech
- sweating
- swelling
- trouble breathing
- unexplained weight loss
Rare
- Black, tarry stools
- bleeding gums
- blood in vomit
- changes in skin color, pain, tenderness, swelling of the foot or leg
- chest pain or tightness
- cough
- coughing up blood
- dark urine
- decreased urine output
- difficulty in breathing or swallowing
- difficulty swallowing
- dilated neck veins
- extreme tiredness or weakness
- fast, irregular, pounding, or racing heartbeat or pulse
- fever
- hives, itching, skin rash
- increased menstrual flow or vaginal bleeding
- irregular breathing
- itching, pain, redness, swelling, tenderness, or warmth on the skin
- light-colored stools
- nosebleeds
- pain in the groin or genitals
- pale skin
- paleness or cold feeling in the fingertips and toes
- paralysis
- pounding in the ears
- prolonged bleeding from cuts
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red or dark brown urine
- severe or continuing stomach pain
- sharp back pain just below the ribs
- sneezing
- sore throat
- swelling of the face, fingers, feet, or lower legs
- tingling or pain in the fingers or toes when exposed to cold temperatures
- tremor
- unusual bleeding or bruising
- upper right abdominal or stomach pain
- yellow eyes and skin
Incidence not known
- Blindness
- bloating
- clear or bloody discharge from nipple
- decreased vision
- delusions of persecution, mistrust, suspiciousness, and/or combativeness
- dimpling of the breast skin
- eye pain
- gaseous
- indigestion
- inverted nipple
- lump in the breast or under the arm
- pain or discomfort in the arms, jaw, back, or neck
- pains in the stomach, side, or abdomen, possibly radiating to the back
- persistent crusting or scaling of the nipple
- pinpoint red spots on the skin
- recurrent fever
- redness of swelling of the breast
- severe constipation
- severe cramping
- sore on the skin of the breast that does not heal
- sores, ulcers, or white spots on the lips or in the mouth
- stomach fullness
- swollen glands
- tearing
- weakness of the muscles in your face
Get emergency help immediately if any of the following symptoms of overdose occur while taking octreotide:
Symptoms of overdose
- Anxiety
- blurred vision
- chills
- cold sweats
- coma
- confusion
- cool, pale skin
- depression
- dizziness
- fast heartbeat
- feeling of warmth
- headache
- increased hunger
- nausea
- nervousness
- nightmares
- redness of the face, neck, arms and occasionally, upper chest
- seizures
- shakiness
- slurred speech
- unusual tiredness or weakness
Other side effects of Bynfezia Pen
Some side effects of octreotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Abnormal stool
- excess air or gas in the stomach or bowels
- full feeling
- pain, redness, stinging, swelling, tingling, or burning sensation at the injection site
- passing of gas
Less common
- Backache
- feeling of warmth
- hair loss
- joint pain
- redness of the face, neck, arms and occasionally, upper chest
Rare
- Absent, missed, or irregular menstrual periods
- change in vision
- difficulty in moving
- feeling of constant movement of self or surroundings
- hearing loss
- itching of the vagina or genital area
- joint swelling or redness
- loss of vision
- memory loss
- muscle pain
- numbness or tingling of the hands, feet, or face
- pain during sexual intercourse
- sensation of spinning
- stopping of menstrual bleeding
- swelling of the breasts or breast soreness in both females and males
- thick, white vaginal discharge with no odor or with a mild odor
- unexpected or excess milk flow from the breasts
Incidence not known
- Decreased interest in sexual intercourse
- inability to have or keep an erection
- loss in sexual ability, desire, drive, or performance
- unexpected or excess milk flow from the breasts
For Healthcare Professionals
Applies to octreotide: injectable solution, intramuscular powder for injection extended release, oral delayed release capsule, subcutaneous solution.
General
The most common adverse events were gastrointestinal disorders, nervous system disorders, hepatobiliary disorders, and metabolism and nutritional disorders.[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (57.9%), abdominal pain (43.9%), nausea (29.8%), flatulence (25.3%), constipation (18.8%), abdominal pain upper (10.5%), abdominal discomfort, loose stools
Common (1% to 10%): Fat malabsorption, vomiting, dyspepsia, steatorrhea, discoloration of feces, tenesmus, abdominal distension
Uncommon (0.1% to 1%): GI bleeding, hemorrhoids, appendicitis, gastric/peptic ulcer
Frequency not reported: Pancreatitis, vomiting, abnormal stools, severe epigastric pain, abdominal tenderness and guarding
Postmarketing reports: Intestinal obstruction[Ref]
Cardiovascular
Very common (10% or more): Bradycardia (25%), hypertension (12.6%), conduction abnormalities (10%)
Common (1% to 10%): Arrhythmias, flushing
Uncommon (0.1% to 1%): Chest pain, shortness of breath, thrombophlebitis, ischemia, congestive heart failure, palpitations, orthostatic blood pressure decrease, tachycardia[Ref]
Hepatic
Very common (10% or more): Gallstones (27%), sludge without stones (24%), cholelithiasis (38.2%), biliary duct dilatation (12%)
Common (1% to 10%): Transaminase increased
Uncommon (0.1% to 1%): Hepatitis, jaundice, increase in liver enzymes, gallbladder polyp
Rare (less than 0.1%): Acute pancreatitis
Frequency not reported: Acute cholecystitis, ascending cholangitis, biliary obstruction, cholestatic hepatitis, pancreatitis[Ref]
Nervous system
Very common (10% or more): Headache (30%), dizziness (20%)
Uncommon (0.1% to 1%): Syncope, tremor, seizure, vertigo, Bell's palsy, pituitary apoplexy, amnesia, neuritis[Ref]
Metabolic
Very common (10% or more): Hyperglycemia (16%)
Common (1% to 10%): Hypoglycemia, edema, anorexia
Uncommon (0.1% to 1%): Weight loss, dehydration
Frequency not reported: Depressed vitamin B12 levels, abnormal Schilling's test[Ref]
Hematologic
Very common (10% or more): Anemia (15.3%)
Uncommon (0.1% to 1%): Iron deficiency
Postmarketing reports: Thrombocytopenia[Ref]
Endocrine
Very common (10% or more): Biochemical hypothyroidism (12%)
Common (1% to 10%): Goiter, thyroid dysfunction (e.g. decreased TSH, decreased Total T4, and decreased Free T4)
Uncommon (0.1% to 1%): Galactorrhea, hypoadrenalism, diabetes insipidus[Ref]
Local
Very common (10% or more): Injection site pain (13.8%), injection site reactions
Common (1% to 10%): Injection site hematoma[Ref]
Dermatologic
Very common (10% or more): Alopecia (13.2%)
Common (1% to 10%): Pruritus, bruise, rash
Uncommon (0.1% to 1%): Cellulitis, petechiae, urticaria, basal cell carcinoma[Ref]
Musculoskeletal
Common (1% to 10%): Joint pain, backache
Uncommon (0.1% to 1%): Arthritis, joint effusion, muscle pain, Raynaud's phenomenon[Ref]
Psychiatric
Common (1% to 10%): Depression
Uncommon (0.1% to 1%): Anxiety, paranoia, libido decrease[Ref]
Other
Very common (10% or more): Fatigue (31.8%), generalized pain (15%)
Common (1% to 10%): Weakness
Uncommon (0.1% to 1%): Hearing loss, otitis[Ref]
Respiratory
Very common (10% or more): Upper respiratory tract infection (18.2%), sinusitis (12%)
Common (1% to 10%): Cold symptoms, flu symptoms, epistaxis
Uncommon (0.1% to 1%): Pneumonia, pulmonary nodule, status asthmaticus[Ref]
Renal
Uncommon (0.1% to 1%): Increased creatinine kinase[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Allergic reaction
Frequency not reported: Anaphylactic reaction[Ref]
Immunologic
Very common (10% or more): Antibodies to octreotide (the active ingredient contained in Bynfezia Pen) (25%)
Ocular
Common (1% to 10%): Blurred vision, visual disturbance
Uncommon (0.1% to 1%): Increased intraocular pressure[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection, pollakiuria
Uncommon (0.1% to 1%): Gynecomastia, amenorrhea, polymenorrhea, oligomenorrhea, vaginitis, nephrolithiasis, hematuria[Ref]
More about Bynfezia Pen (octreotide)
- Check interactions
- Compare alternatives
- Latest FDA alerts (1)
- Dosage information
- During pregnancy
- Drug class: somatostatin and somatostatin analogs
- Breastfeeding
- En español
Patient resources
Other brands
Sandostatin, Sandostatin LAR Depot, Mycapssa
Professional resources
Other brands
Related treatment guides
References
1. Product Information. Sandostatin (octreotide). Sandoz Pharmaceuticals Corporation. 2001;PROD.
2. Product Information. Octreotide Acetate (octreotide). Teva SICOR Pharmaceuticals Inc. 2005.
3. Cerner Multum, Inc. UK Summary of Product Characteristics.
4. Cerner Multum, Inc. Australian Product Information.
5. Product Information. SandoSTATIN LAR Depot (octreotide). Novartis Consumer Health. 2016.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.