Betamethasone / clotrimazole topical Side Effects

Not all side effects for betamethasone / clotrimazole topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to betamethasone / clotrimazole topical: topical cream, topical lotion

Along with its needed effects, betamethasone / clotrimazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betamethasone / clotrimazole topical:

Less common
  • Blistering, burning, itching, peeling, dryness, redness, or other signs of skin irritation not present before use of this medicine
  • burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
  • hives
Rare
  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • rash
  • stinging
  • swelling
Incidence not known
  • Abdominal pain
  • backache
  • blurred vision
  • dry mouth
  • facial hair growth in females
  • flushed, dry skin
  • fractures
  • fruit-like breath odor
  • full or round face, neck, or trunk
  • increased hunger, thirst, or urination
  • irritability
  • loss of sexual desire or ability
  • menstrual irregularities
  • muscle wasting
  • nausea
  • sugar in the urine
  • sweating
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting

Check with your doctor as soon as possible if any of the following side effects occur while taking betamethasone / clotrimazole topical:

Incidence not known
  • Acne or oily skin
  • increased hair growth, especially on the face and body
  • increased loss of hair, especially on the scalp
  • pus in the hair follicles
  • reddish purple lines on arms, face, legs, trunk, or groin
  • redness and scaling around the mouth
  • softening of the skin
  • thinning of skin with easy bruising
  • white spots

For Healthcare Professionals

Applies to betamethasone / clotrimazole topical: topical cream, topical lotion

Local

Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axilla, and groin appears to be most susceptible to the adverse long-term effects of topical betamethasone. Use of high potency topical corticosteroids on these areas should be minimized or avoided.

Topical corticosteroid use may impair local immune response rendering the skin more susceptible to infections. Folliculitis is occasionally reported.

Perioral dermatitis or rosacea-like dermatitis has occurred patients treated with potent topical corticosteroids who are of seborrheic skin type. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.

Worsening of psoriasis has occurred in a few patients.

Local side effects have commonly included burning, itching, dryness, or irritation, especially if applied to denuded skin. Allergic contact dermatitis has occasionally been reported. Long-term use of topical corticosteroids has resulted in skin atrophy and thinning, and the development of striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding.

Endocrine

Endocrinologic side effects have included suppression of the hypothalamic-pituitary-adrenal axis and has resulted in Cushing's Syndrome and symptoms of adrenal suppression following withdrawal of the drug. This has been more common when higher potency topical corticosteroids were used over extensive areas and when occlusive dressing were used.

Adrenal suppression has been reported in patients with psoriasis using betamethasone dipropionate. Plasma cortisol concentrations generally return to normal within one to two weeks following discontinuation of the drug, and in some cases returned to normal during continued therapy.

If betamethasone dipropionate is to be used for an extended period to time, adrenal function should be evaluated periodically. Supplemental systemic steroids may be necessary during times of stress.

Ocular

Ocular side effects have included rare reports of glaucoma in patients who used betamethasone on the face for long periods of time. Intraocular pressure did not always return to normal following discontinuation of the drug.

Steroid-induced cataracts and glaucoma have been reported, most often in patients receiving betamethasone eyedrops (not available in the US). In one patient, permanent eye damage resulted from long-term application of betamethasone cream to the eyelids.

Musculoskeletal

Musculoskeletal side effect have included rare reports of osteoporosis in long-term betamethasone use. Vertebral fractures and avascular necrosis of the hips has been documented.

Dermatologic

Betamethasone-clotrimazole topical is not recommended for the treatment of diaper dermatitis. Adverse events consistent with corticosteroid use have been observed in patients treated for diaper dermatitis.

Dermatologic side effects have included rash, edema, dry skin, burning and stinging.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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