Aphexda Side Effects

Generic name: motixafortide

Medically reviewed by Drugs.com. Last updated on Nov 15, 2023.

Note: This document contains side effect information about motixafortide. Some dosage forms listed on this page may not apply to the brand name Aphexda.

Applies to motixafortide: subcutaneous powder for solution.

Serious side effects of Aphexda

Along with its needed effects, motixafortide (the active ingredient contained in Aphexda) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking motixafortide:

More common

• Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
• blurred vision
• chest tightness
• chills
• confusion
• cough
• decreased urine
• difficulty in breathing or swallowing
• dizziness
• dry mouth
• eye pain
• fast heartbeat
• feeling of warmth
• fever
• general feeling of illness
• headache
• increased thirst
• loss of appetite
• mood changes
• muscle pain or cramps
• nausea or vomiting
• nervousness
• numbness or tingling in the hands, feet, or lips
• pounding in the ears
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness of the face, neck, arms, and occasionally, upper chest
• seizures
• shakiness in the legs, arms, hands, or feet
• skin itching, rash, or redness
• sore throat
• swelling of the face, throat, or tongue
• trembling or shaking of the hands or feet
• unusual tiredness or weakness

Other side effects of Aphexda

Some side effects of motixafortide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Back pain
• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
• cracked, dry, scaly skin
• ear swelling
• swelling

For Healthcare Professionals

Applies to motixafortide: subcutaneous powder for injection.

General

Most common adverse reactions (incidence greater than 20%) are injection site reactions, injection site pain, injection site erythema, injection site pruritus, pruritus, flushing, and back pain.^[Ref]

Cardiovascular

Frequency not reported: Hypertension

Dermatologic

Very common (10% or more): Pruritus (38%), rash (16%), urticaria (14%), erythema (12%)

Frequency not reported: Dermatitis exfoliative generalized

Rash included rash erythematous, rash maculo-papular, rash papular and rash pruritic.

Gastrointestinal

Very common (10% or more): Nausea (14%)

Hematologic

Very common (10% or more): Flushing (33%)

Frequency not reported: Leukocytosis

Flushing included hot flush.

Hypersensitivity

Frequency not reported: Anaphylactic shock and hypersensitivity reactions

Local

Very common (10% or more): Injection site reactions (73%; injection site pain [53%], injection site erythema [27%], injection site pruritus [24%])

Injection site reactions included injection site bruising, injection site discomfort, injection site erythema, injection site induration, injection site mass, injection site nodule, injection site pain, injection site pruritus, injection site rash, injection site swelling, injection site urticaria, injection site cellulitis and injection related reaction.

Metabolic

Very common (10% or more): Hypokalemia (15%)

Musculoskeletal

Very common (10% or more): Back pain (21%)

Back pain included spinal pain and sacral pain.

Nervous system

Very common (10% or more): Paresthesia (19%)

Frequency not reported: Dizziness, tremor

Paresthesia included paresthesia oral, hypoesthesia, hypoesthesia oral and burning sensation.

Other

Frequency not reported: Ear swelling, pyrexia, chills

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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