Motixafortide

Generic name: motixafortide
Brand name: Aphexda
Dosage form: subcutaneous powder for injection (62 mg)
Drug class: Hematopoietic stem cell mobilizer

Medically reviewed by Drugs.com on Jan 16, 2024. Written by Cerner Multum.

What is motixafortide?

Motixafortide is used in combination with another medicine to help increase the number of stem cells for collection before a stem cell transplant in adults with multiple myeloma.

Motixafortide may also be used for purposes not listed in this medication guide.

Motixafortide side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Motixafortide may cause serious side effects. Call your doctor at once if you have:

• chills;

• vomiting, nausea;

• itching, rash; or

• flushing (sudden warmth, redness, or tingly feeling).

Common side effects of motixafortide may include:

• pain, bruising, swelling, redness, itching, or irritation where the medicine was injected;

• flushing; or

• back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Tecvayli, Revlimid, Darzalex, Velcade, Pomalyst, Kyprolis, plerixafor

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use motixafortide if you are allergic to it.

Motixafortide should not be used in people with leukemia.

Tell your doctor if you have or have ever had:

• blood or bone marrow cancer.

You will need to take a pregnancy test before treatment with motixafortide.

May harm an unborn baby. Do not use if you are pregnant. Use effective birth control while using motixafortide and for at least 8 days after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using motixafortide, and for at least 8 days after your last dose.

How is motixafortide given?

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Motixafortide is injected under the skin by a healthcare professional.

Doses are based on weight. Your dose may change if you gain or lose weight.

You may be given other medications to help prevent serious side effects or allergic reaction. Keep taking these medicines for as long as your doctor has prescribed.

You will be watched for one hour to make sure you do not have an allergic reaction.

Your blood will need to be tested often.

Follow all storage instructions provided with motixafortide. Your pharmacist can provide more information about how to store this medicine.

Motixafortide dosing information

Usual Adult Dose for Multiple Myeloma:

1.25 mg/kg via slow (approximately 2 minutes) subcutaneous injection 10 to 14 hours prior to the initiation of the first apheresis

Comments:
-Premedicate all patients before each dose of this drug to reduce the risk of hypersensitivity and injection site reactions. Administer approximately 30 to 60 minutes before injection of this drug:
---Diphenhydramine (12.5 mg IV or 25 mg to 50 mg orally, or another H1-antihistamine)
---H2 blocker (e.g., famotidine)
---Leukotriene inhibitor (e.g., montelukast)
---The addition of an analgesic medication (e.g., acetaminophen) to the premedication regimen is recommended.
-A second dose of this drug can be administered 10 to 14 hours before a third apheresis, if necessary
-Inject filgrastim at a dose of 10 mcg/kg of the patient's actual body weight subcutaneously once a day for 4 days leading up to the initial dose of this medication, and then on each day prior to every apheresis session.
-Dosing is based on actual body weight.
-If required, a second dose of this medication can be administered 10 to 14 hours before a third apheresis procedure.

Use: To mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with multiple myeloma

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your motixafortide injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while receiving motixafortide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect motixafortide?

Other drugs may affect motixafortide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2024 Cerner Multum, Inc. Version: 1.01.