Antivenin (crotalidae) polyvalent Side Effects

Some side effects of antivenin (crotalidae) polyvalent may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to antivenin (crotalidae) polyvalent: intravenous powder for solution

Along with its needed effects, antivenin (crotalidae) polyvalent may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking antivenin (crotalidae) polyvalent:

• Unexplained bleeding or bruising

• Cough
• difficulty in breathing
• difficulty in swallowing
• dizziness or lightheadedness
• fast heartbeat
• fever
• hives or welts
• itching of skin
• joint pain
• large, hive-like swellings on the eyelids, face, lips, mouth, and/or tongue
• muscle pain
• noisy breathing
• redness of skin
• shortness of breath
• skin rash
• wheezing

Check with your doctor as soon as possible if any of the following side effects occur while taking antivenin (crotalidae) polyvalent:

• Areas of pain, redness, and swelling
• chest pain
• chills
• discharge from wound
• pain, tenderness, and warmth at wound site
• unusual tiredness or weakness

Some side effects of antivenin (crotalidae) polyvalent may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Nausea

For Healthcare Professionals

Applies to antivenin (crotalidae) polyvalent: injectable solution

Hypersensitivity

Hypersensitivity reactions have included immediate systemic reactions such as anaphylaxis and shock, characterized by apprehension, flushing, itching, urticaria, edema of the face, tongue, and throat, cough, dyspnea, cyanosis, vomiting, and collapse. Cardiac arrest and death have been reported rarely. Immediate-hypersensitivity reactions occurred in less than 1% of patients with negative skin tests.

Serum sickness may occur 5 to 24 days after administration of antivenin. Symptoms may include fever, malaise, urticaria, lymphadenopathy, edema, arthralgia, nausea, vomiting, meningismus, peripheral neuritis, pain, muscle weakness, and permanent atrophy. Serum sickness may occur within less than 5 days, especially in patients who have previously received horse serum. Its frequency may be related to the number of vials the patient has received.

Nervous system

Nervous system side effects have included meningismus, peripheral neuritis, pain, circumoral paresthesia, general paresthesia, nervousness, and permanent atrophy.

Hematologic

Hematologic side effects have included coagulation disorder and ecchymosis.

Cardiovascular

Cardiovascular side effects have included hypotension.

Dermatologic

Dermatologic side effects have included rash and subcutaneous nodule.

Respiratory

Respiratory side effects have included asthma, cough, and increased sputum.

Musculoskeletal

Musculoskeletal side effects have included myalgia and muscle weakness.

Gastrointestinal

Gastrointestinal side effects have included nausea and anorexia.

Other

Other side effects have included back pain, chest pain, cellulitis, wound infection, and chills.

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