Amlobenz Side Effects

Generic Name: amlodipine / benazepril

Note: This page contains information about the side effects of amlodipine / benazepril. Some of the dosage forms included on this document may not apply to the brand name Amlobenz.

Not all side effects for Amlobenz may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to amlodipine / benazepril: oral capsule

In addition to its needed effects, some unwanted effects may be caused by amlodipine / benazepril. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking amlodipine / benazepril:

Less common
  • Confusion
  • dizziness, lightheadedness, or fainting
  • fast or irregular heartbeat
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • swelling of the ankles, feet, or lower legs
  • weakness or heaviness of the legs
Rare
  • Bleeding gums
  • chills
  • fever
  • nausea or vomiting
  • nosebleeds
  • pale skin
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • stomach pain or bloating with fever, nausea, or vomiting
  • swelling of the face, mouth, hands, or feet
  • trouble with swallowing or breathing (sudden) or hoarseness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin
Incidence not known
  • Chest pain
  • heartburn
  • pain or burning in the throat

Some of the side effects that can occur with amlodipine / benazepril may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Cough (dry and continues)
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally upper chest
  • sleepiness
Incidence not known
  • Acid or sour stomach
  • belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • body aches or pain
  • cracked, dry, or scaly skin
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • frequent urination
  • inability to have or keep an erection
  • increased volume of pale, dilute urine
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • muscle or bone pain
  • shakiness in the legs, arms, hands, or feet
  • stomach discomfort or upset
  • sudden sweating
  • swelling
  • tender, swollen glands in the neck
  • trembling or shaking of the hands or feet
  • trouble with sleeping
  • voice changes

For Healthcare Professionals

Applies to amlodipine / benazepril: oral capsule

General

The most common side effects were cough, headache, dizziness, and edema.[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Frequency not reported: Tremor

Amlodipine:
Common (1% to 10%): Headache, dizziness
Postmarketing reports: Dysgeusia, hypoesthesia, paresthesia, syncope, peripheral neuropathy, hypertonia

Benazepril:
Common (1% to 10%): Headache, dizziness
Postmarketing reports: Paresthesia, dysgeusia[Ref]

Respiratory

Common (1% to 10%): Cough
Frequency not reported: Pharyngitis

Amlodipine:
Uncommon (0.1% to 1%): Cough
Postmarketing reports: Rhinitis

Benazepril:
Common (1% to 10%): Cough[Ref]

Other

Common (1% to 10%): Edema
Frequency not reported: Asthenia, fatigue

Amlodipine:
Common (1% to 10%): Edema
Postmarketing reports: Malaise

Benazepril:
Uncommon (0.1% to 1%): Edema[Ref]

Amlodipine-induced peripheral edema is dose dependent. Benazepril reduces the incidence of edema when added to amlodipine.[Ref]

Genitourinary

Frequency not reported: Impotence, polyuria

Amlodipine:
Postmarketing reports: Micturition disorder, nocturia, erectile dysfunction[Ref]

Gastrointestinal

Frequency not reported: Dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis

Amlodipine:
Postmarketing reports: Gingival hyperplasia, gastritis[Ref]

Musculoskeletal

Frequency not reported: Back pain, musculoskeletal pain, cramps, muscle cramps

Amlodipine:
Postmarketing reports: Muscle spasms, arthralgia

Benazepril:
Postmarketing reports: Arthralgia, arthritis, myalgia[Ref]

Dermatologic

Frequency not reported: Rash, skin nodule, dermatitis

Amlodipine:
Postmarketing reports: Hyperhidrosis, pruritus, skin discoloration, urticaria, erythema multiform

Benazepril:
Postmarketing reports: Stevens-Johnson syndrome, pemphigus, pruritus, photosensitivity reaction[Ref]

Psychiatric

Frequency not reported: Insomnia, nervousness, anxiety, libido decreased[Ref]

Cardiovascular

Frequency not reported: Flushing, hot flashes

Amlodipine:
Postmarketing reports: Tachycardia, hypotension, vasculitis

Benazepril:
Postmarketing reports: Orthostatic symptoms, hypotension, angina pectoris, arrhythmia[Ref]

Ocular

Amlodipine:
Postmarketing reports: Visual impairment, diplopia

Benazepril:
Postmarketing reports: Impaired vision[Ref]

Metabolic

Frequency not reported: Hypokalemia

Amlodipine:
Postmarketing reports: Hyperglycemia, weight decrease or gain[Ref]

Immunologic

Amlodipine:
Postmarketing reports: Allergic reaction[Ref]

Renal

Benazepril
Postmarketing reports: Serum creatinine increased, BUN increased, renal impairment[Ref]

Hematologic

Frequency not reported: Neutropenia

Amlodipine:
Postmarketing reports: Leucocytopenia

Benazepril:
Postmarketing reports: Hemolytic anemia, thrombocytopenia, agranulocytosis, neutropenia[Ref]

Hepatic

Amlodipine:
Postmarketing reports: Jaundice, hepatic enzyme elevations

Benazepril:
Postmarketing reports: Pancreatitis[Ref]

References

1. "Product Information. Lotrel (amlodipine-benazepril)." Ciba Pharmaceuticals, Summit, NJ.

More about Amlobenz (amlodipine / benazepril)

Consumer resources

Professional resources

Related treatment guides

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