Acyclovir topical Side Effects

Some side effects of acyclovir topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to acyclovir topical: topical cream, topical ointment

Get emergency medical help if you have any of these signs of an allergic reaction while taking acyclovir topical: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects of acyclovir topical may include:

• dry, cracked, or peeling lips;

• dryness or flaking of treated skin;

• burning, stinging, or itching when the medicine is applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to acyclovir topical: topical cream, topical ointment

General

Acyclovir topical has been generally well tolerated and adverse effects are uncommon.

Local

Local side effects associated with the ointment have included mild pain (including transient stinging and burning) and local pruritus. Dryness of skin, flakiness of skin, dry lips, cracked lips, burning skin, pruritus, and stinging on skin have been reported at the site of topical application in less than 1% of patients using acyclovir topical cream. Edema and/or pain at the application site have been reported during postmarketing experience with acyclovir topical ointment. The pain is generally due to manipulation of the herpetic lesions rather than a reaction to the drug itself. Application site reactions (including signs and symptoms of inflammation) have been reported during postmarketing experience with acyclovir topical cream.

Dermatologic

Dermatologic side effects have included rash and pruritus during postmarketing experience with acyclovir topical ointment. Contact dermatitis and eczema have been reported during postmarketing experience with acyclovir topical cream.

Hypersensitivity

Hypersensitivity side effects have included angioedema and anaphylaxis during postmarketing experience with acyclovir topical cream.

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