Acyclovir topical Side Effects

Not all side effects for acyclovir topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to acyclovir topical: topical cream, topical ointment

Along with its needed effects, acyclovir topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of acyclovir topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Mild pain, burning, or stinging
Less common
  • Itching
Rare
  • Itching, stinging, or redness of the genital area
  • skin rash

For Healthcare Professionals

Applies to acyclovir topical: topical cream, topical ointment

General

Acyclovir topical has been generally well tolerated and adverse effects are uncommon.

Local

Local side effects associated with the ointment have included mild pain (including transient stinging and burning) and local pruritus. Dryness of skin, flakiness of skin, dry lips, cracked lips, burning skin, pruritus, and stinging on skin have been reported at the site of topical application in less than 1% of patients using acyclovir topical cream. Edema and/or pain at the application site have been reported during postmarketing experience with acyclovir topical ointment. The pain is generally due to manipulation of the herpetic lesions rather than a reaction to the drug itself. Application site reactions (including signs and symptoms of inflammation) have been reported during postmarketing experience with acyclovir topical cream.

Dermatologic

Dermatologic side effects have included rash and pruritus during postmarketing experience with acyclovir topical ointment. Contact dermatitis and eczema have been reported during postmarketing experience with acyclovir topical cream.

Hypersensitivity

Hypersensitivity side effects have included angioedema and anaphylaxis during postmarketing experience with acyclovir topical cream.

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