Acyclovir use while Breastfeeding

Drugs containing Acyclovir: Zovirax, Zovirax Ointment, Zovirax Cream, Sitavig, Xerese, Lipsovir

Acyclovir Levels and Effects while Breastfeeding

Summary of Use during Lactation

Even with the highest maternal dosages, the dosage of acyclovir in milk is only about 1% of a typical infant dosage and would not be expected to cause any adverse effects in breastfed infants. Topical acyclovir applied to small areas of the mother's body away from the breast should pose no risk to the infant. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[1]

Drug Levels

Maternal Levels. A 4-month-postpartum women was taking 200 mg orally 5 times daily every 4 hours while awake. After 4 days of therapy, milk samples were taken 9 hours after the previous dose and at 4 times after a 200 mg dose. The lowest milk level of 427 mcg/L occurred 30 minutes after the first dose. At 3.2 hours after the dose, the milk acyclovir level was 1.3 mg/L and apparently still increasing.[2]

A woman who was 1 year postpartum was taking acyclovir 200 mg orally 5 times daily. Milk levels taken immediately before a dose during 5 days of therapy ranged from 0.78 to 1.07 mg/L. Samples taken after the last dose decreased with a half-life of 2.8 hours.[3]

A woman who had taken oral acyclovir 400 mg 3 times daily for 3 days in the peripartum period had a breastmilk acyclovir level of 54 mcg/L 5 days after her last dose of acyclovir.[4] A mother nursing her 7-month-old infant took acyclovir 800 mg orally 5 times a day. Three milk acyclovir levels on days 5 and 6 of therapy ranged from 4.2 to 5.8 mg/L, with the highest level 9.4 hours after the previous dose. The authors estimated that a fully breastfed infant would receive 0.73 mg/kg/day of acyclovir at this maternal dosage or about 1% of the maternal weight-adjusted dosage.[5]

A woman who was 6 weeks postpartum received intravenous acyclovir 300 mg (5 mg/kg) 3 times daily for 5 days. Milk samples were taken every 6 hours after the last dose. The peak level was 7.3 mg/L and the drug was detectable in milk for up to 88 hours after the last dose.[6] Using the level 6 hours after the last dose, a fully breastfed infant would receive 1.1 mg/kg/day with this maternal dosage regimen.

Acyclovir is given to neonates in intravenous dosages of 20 to30 mg/kg daily. Dosages received in breastmilk with high maternal doses are only about 3 to 5% of this dose. Because the infant receives breastmilk doses orally and acyclovir is only about 20% orally bioavailable,[5] the systemic dosage that the nursing infant receives is 1% or less of a typical infant dosage.

Infant Levels. A 4-month-old infant whose mother was taking 200 mg orally 5 times was breastfed just before a dose. The infant's urine collected over the next 2 hours contained a total of 27 mcg of acyclovir.[2]

Effects in Breastfed Infants

The mother of a 4-month-old infant noticed no adverse effects in her breastfed infant while she was taking an acyclovir dosage of 800 mg orally 5 times daily.[5]

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Valacyclovir

References

1. Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. PMID: 14623482

2. Lau RJ, Emery MG, Galinsky RE. Unexpected accumulation of acyclovir in breast milk with estimation of infant exposure. Obstet Gynecol. 1987;69 (3 pt 2):468-71. PMID: 3808527

3. Meyer LJ, de Miranda P, Sheth N et al. Acyclovir in human breast milk. Am J Obstet Gynecol. 1988;158(3 pt 1):586-8. PMID: 3348321

4. Frenkel LM, Brown ZA, Bryson YJ et al. Pharmacokinetics of acyclovir in the term human pregnancy and neonate. Am J Obstet Gynecol. 1991;164:569-76. PMID: 1847004

5. Taddio A, Klein J, Koren G. Acyclovir excretion in human breast milk. Ann Pharmacother. 1994;28:585-7. PMID: 8068994

6. Bork K, Benes P. Concentration and kinetic studies of intravenous acyclovir in serum and breast milk of a patient with eczema herpeticum. J Am Acad Dermatol. 1995;32:1053-5. PMID: 7751454

Acyclovir Identification

Substance Name

Acyclovir

CAS Registry Number

59277-89-3

Drug Class

Antiinfective Agents

Antiviral Agents

Administrative Information

LactMed Record Number

331

Last Revision Date

20130907

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