Abelcet Side Effects

Generic name: amphotericin b lipid complex

Medically reviewed by Drugs.com. Last updated on Dec 2, 2023.

Note: This document provides detailed information about Abelcet Side Effects associated with amphotericin b lipid complex. Some dosage forms listed on this page may not apply specifically to the brand name Abelcet.

Applies to amphotericin b lipid complex: suspension.

Serious side effects of Abelcet

Along with its needed effects, amphotericin b lipid complex (the active ingredient contained in Abelcet) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amphotericin b lipid complex:

More common

• chills and fever
• headache
• nausea and vomiting

Less common

• difficulty in breathing
• sore throat and fever
• unusual bleeding or bruising
• unusual tiredness and weakness

Rare

• increased or decreased urination

Other side effects of Abelcet

Some side effects of amphotericin b lipid complex may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• diarrhea
• loss of appetite
• stomach pain

For healthcare professionals

Applies to amphotericin b lipid complex: intravenous suspension.

General

The most common clinical side effects in clinical trials were chills, increased creatinine, pyrexia, hypokalemia, nausea, and vomiting.^[Ref]

Other

• Very common (10% or more): Chills (up to 18%), fever/pyrexia (up to 14%), multiple organ failure (11%)
• Common (1% to 10%): Sepsis, infection, pain, chest pain, increased alkaline phosphatase
• Frequency not reported: Malaise, weight loss, increased lactate dehydrogenase, shivering, generalized edema, asthenia, peripheral edema

Renal

• Very common (10% or more): Increased serum creatinine (up to 13%)
• Common (1% to 10%): Renal failure, renal impairment, increased BUN/urea
• Frequency not reported: Decreased renal function, abnormal kidney function
• Postmarketing reports: Renal tubular acidosis (including hyposthenuria, electrolyte imbalance [e.g., increased potassium, decreased magnesium]), nephrogenic diabetes insipidus^[Ref]

Metabolic

• Common (1% to 10%): Hypokalemia, electrolyte imbalance (including increased blood potassium, decreased blood magnesium)
• Frequency not reported: Anorexia, hypomagnesemia, hyperkalemia, hypocalcemia, hypercalcemia, acidosis, hyperamylasemia, hypoglycemia, hyperglycemia, hyperuricemia, hypophosphatemia, hypernatremia, hyponatremia, hyperchloremia
• Postmarketing reports: Hyperammonemia^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting, diarrhea, gastrointestinal hemorrhage, abdominal pain, nausea and vomiting
• Frequency not reported: Melena, dyspepsia, epigastric pain, cramping, constipation
• Postmarketing reports: Peritonitis^[Ref]

Hematologic

• Common (1% to 10%): Thrombocytopenia, leukopenia, anemia
• Frequency not reported: Coagulation defects, blood dyscrasias (including eosinophilia), leukocytosis, decreased thromboplastin
• Postmarketing reports: Pancytopenia^[Ref]

Nervous system

• Common (1% to 10%): Headache, tremor
• Uncommon (0.1% to 1%): Convulsions, neuropathy
• Frequency not reported: Peripheral neuropathy, deafness, hearing loss, tinnitus, transient vertigo, cerebral vascular accident, extrapyramidal syndrome, other neurologic symptoms, somnolence
• Postmarketing reports: Encephalopathy, stupor^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Anaphylactic response
• Frequency not reported: Anaphylaxis, allergic reactions (including bronchospasm, wheezing, asthma), anaphylactoid reactions, infusion hypersensitivity reactions (including abdominal pain, nausea, vomiting, myalgia, pruritus, maculopapular rash, fever, hypotension, shock, bronchospasm, respiratory failure)^[Ref]

Cardiovascular

• Common (1% to 10%): Hypotension, cardiac arrest, hypertension, tachycardia, cardiac arrhythmias
• Uncommon (0.1% to 1%): Shock
• Frequency not reported: Cardiac failure, myocardial infarction, thrombophlebitis, cardiomyopathy, arrhythmias, ventricular fibrillation, atrial fibrillation, phlebitis, supraventricular tachycardia, abnormal ECG, cyanosis
• Postmarketing reports: Asystole, bradycardia, hemorrhage, vasodilation^[Ref]

Respiratory

• Common (1% to 10%): Respiratory failure, dyspnea, pneumonia, respiratory disorder, asthma
• Frequency not reported: Wheezing, pulmonary edema, hemoptysis, tachypnea, pulmonary embolus, pleural effusion, hypoxia, lung disorder, pneumonia, hyperventilation, increased cough, pharyngitis, apnea
• Postmarketing reports: Bronchospasm^[Ref]

Dermatologic

• Common (1% to 10%): Rash
• Uncommon (0.1% to 1%): Pruritus
• Frequency not reported: Maculopapular rash, erythema multiforme, skin ulcer, exanthema
• Postmarketing reports: Exfoliative dermatitis^[Ref]

Local

• Uncommon (0.1% to 1%): Injection site reaction
• Frequency not reported: Injection site inflammation, injection site hypersensitivity^[Ref]

Musculoskeletal

• Uncommon (0.1% to 1%): Myalgia
• Frequency not reported: Myasthenia, bone pain, joint pain, muscle pain^[Ref]

Hepatic

• Common (1% to 10%): Hyperbilirubinemia, abnormal liver function tests
• Frequency not reported: Acute liver failure, jaundice, hepatitis, increased AST, increased ALT, veno-occlusive liver disease, hepatomegaly, cholangitis, cholecystitis, bilirubinemia^[Ref]

Genitourinary

• Frequency not reported: Oliguria, anuria, impotence, dysuria, hematuria, urinary tract infection, pyuria, urinary tract disorder
• Postmarketing reports: Hyposthenuria, incontinence^[Ref]

Ocular

• Frequency not reported: Visual impairment, diplopia

Psychiatric

• Frequency not reported: Confusion, insomnia, anxiety
• Postmarketing reports: Agitation

Further information

Abelcet side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer