Pronunciation: OH-loe-PA-ta-deen HYE-droe-KLOR-ide
- Solution, ophthalmic 0.2%
- Nasal spray 0.6%
- Solution, ophthalmic 0.1%
Inhibits release of histamine from mast cells and relatively selective histamine H 1 antagonist. Inhibits type 1 immediate hypersensitivity reactions.
T max is 30 to 60 min, C max is 16 ng/mL, average absolute bioavailability is 57% (intranasal).
Protein binding is approximately 55%.
Not extensively metabolized.
Plasma elimination half-life is 3 h (ophthalmic) and 8 to 12 h (intranasal), mainly through urinary excretion.
Special PopulationsRenal Function Impairment
Mean plasma AUC 0-12 is 2-fold higher. No dosage adjustment is required.Hepatic Function Impairment
Effects have not been established. No dosage adjustment is required.Children
6 to 11 yr of age
Mean C max was approximately 2-fold less when compared with adults (intranasal).Gender
C max and AUC were 40% and 27% higher, respectively, in women compared with men (intranasal).Race
The effects of race have not been adequately investigated.
Indications and Usage
Temporary relief of itching caused by allergic conjunctivitis (ophthalmic); relief of symptoms of seasonal allergic rhinitis (intranasal).
None well documented.
Dosage and AdministrationAdults and Children
Ophthalmic 1 to 2 drops in affected eye(s) twice daily, 6 to 8 h apart (0.1% solution). 1 drop in affected eye(s) once daily (0.2% solution). If using other topical ophthalmic drugs, separate each medication by 5 min or more.Adults and Children 12 yr of age and older
Intranasal 2 sprays per nostril twice daily.Children 6 to 11 yr of age
Intranasal 1 spray per nostril twice daily.
- Do not instill while wearing contact lenses.
- Prime the nasal spray by releasing 5 sprays, or until a fine mist appears. When not in use for more than 7 days, re-prime by releasing 2 sprays.
- Discard nasal device after 240 sprays have been used.
Store between 39° and 77°F. Keep bottle tightly closed.
Drug InteractionsAlcohol, CNS depressants
Avoid concurrent use (intranasal) because additional reductions in alertness and impaired CNS function could occur.
Asthenia (5% or less); headache (4%); fatigue, somnolence (1%); depression or worsening of depression.
Bitter taste (13%); nausea, taste perversion.
Blurred vision; burning, dry eye, foreign body sensation, hyperemia, keratitis, lid edema, pruritus, stinging (5% or less).
Upper respiratory tract infection (3%); pharyngolaryngeal pain (2%); cough, nasopharyngitis (1%).
Epistaxis (25%); nasal ulceration (10%); postnasal drip (2%); dry mouth, throat irritation (1%); rhinitis, sinusitis.
CPK elevation, influenza, pyrexia, rash, UTI (1%); dysgeusia, flu syndrome, weight increase.
Perform nasal examinations periodically (intranasal)
Category C .
Safety and effectiveness in children younger than 3 yr of age are not established (ophthalmic); safety and effectiveness in children younger than 6 yr of age not established (intranasal).
Use caution in dose selection, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
- Advise patient that usual dose is 1 drop in affected eye(s) twice daily at an interval of 6 to 8 h (0.1% solution) or 1 drop once daily in the affected eye(s) (0.2% solution).
- Teach patient proper technique for instilling eye drops: wash hands; do not allow dropper to touch eye; tilt head back, look up; pull lower eyelid down; instill prescribed number of drops; close eye for 1 to 2 min and apply gentle pressure to bridge of nose; do not rub eye.
- Advise patients who wear contact lenses to remove their lenses before instilling this medicine and to wait at least 10 min after instilling eye drop before inserting their lenses. Also, caution these patients to not wear their lens if the eye is red.
- Advise patient that if more than 1 topical ophthalmic drug is being used, to administer the drugs at least 5 min apart.
- Advise patient to inform health care provider if experiencing side effects or if eye symptoms do not improve or worsen.
- Advise patients to avoid spraying nasal spray in their eyes.
- Advise patient to avoid engaging in hazardous occupations requiring complete mental alertness (eg, driving).
- Inform patients that the nasal spray adverse reactions (eg, bitter taste, epistaxis, nasal ulcerations, postnasal drip) may occur and to inform their health care provider if these symptoms do not improve.
- Advise patients to avoid concurrent use with alcohol or other CNS depressants.
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