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Hydrocortisone Acetate / Pramoxine Hydrochloride

Pronunciation: HIGH-droe-core-tih-sone ASS-uh-TATE /pram-OX-een HIGH-droe-KLOR-ide
Class: Corticosteroid combination

Trade Names

- Cream 1% hydrocortisone/1% pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine
- Lotion 2.5% hydrocortisone/1% pramoxine

- Lotion 1% hydrocortisone/1% pramoxine

- Foam 1% hydrocortisone/1% pramoxine

HC Pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine

- Cream 1% hydrocortisone/1% pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine
- Lotion 1% hydrocortisone/1% pramoxine
- Lotion 2.5% hydrocortisone/1% pramoxine
- Ointment 1% hydrocortisone/1% pramoxine
- Ointment 2.5% hydrocortisone/1% pramoxine

- Foam 1% hydrocortisone/1% pramoxine



Depresses formation, release and activity of endogenous mediators of inflammation, as well as modifying body's immune response.

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Stabilizes the neuronal membrane of nerve endings with which it comes in contact.

Indications and Usage

Topical relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.


History of hypersensitivity to any component of the product.

Dosage and Administration


Apply to the affected area as a thin film 3 or 4 times daily, depending on severity of the condition. Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen.

General Advice

  • For topical use only. Not for ophthalmic or otic use.
  • Do not apply an occlusive dressing unless ordered by health care provider.


Store at controlled room temperature (59° to 86°F). Keep tube tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Burning; itching; irritation; dryness; folliculitis; hypertrichosis; acneiform eruptions; hyperpigmentation; perioral dermatitis; allergic contact dermatitis; maceration of the skin; secondary infection; skin atrophy; striae; miliaria.



Category C .


Undetermined; however, systemic hydrocortisone is excreted in breast milk.


Children may demonstrate greater susceptibility to topical corticosteroids-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing syndrome than mature patients because of a larger skin surface area to body weight ratio.

Topical absorption

Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression, manifestations of Cushing syndrome, hyperglycemia, and glucosuria.



HPA axis suppression; manifestations of Cushing syndrome, hyperglycemia, and glucosuria, especially when large surface areas, prolonged use, or occlusive dressings are involved.

Patient Information

  • Review prescribed dosing schedule with patient or caregiver.
  • Remind patient or caregiver that cream is not to be used in the eye or ear.
  • Teach patient or caregiver proper technique for applying product: wash hands; apply thin film to affected area(s) using fingers or applicator. Wash hands after applying product.
  • Caution patient or caregiver to not cover area with an occlusive dressing unless advised by health care provider.
  • Advise patient or caregiver to contact health care provider if local redness or swelling develops or if skin lesions do not improve or worsen.

Copyright © 2009 Wolters Kluwer Health.