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Hops

Scientific names: Humulus lupulus

Efficacy-safety rating:

ÒÒ...Ethno or other evidence of efficacy.

Safety rating:

...Little exposure or very minor concerns.

What is Hops?

Hops is a perennial climbing vine extensively cultivated worldwide. Male and female flowers are located on separate plants. The cone-shaped fruits (known as strobiles) are collected in the fall and carefully dried. Hops is a member of the Cannabaceae (marijuana) family.

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What is it used for?

Traditional/Ethnobotanical uses

Hops have been used for centuries to flavor and preserve beer. The bitter, aromatic taste of beer mostly is due to the hops content. Hops extracts also are used for other flavoring purposes in the food industry. Hops pickers have reported sedation during harvest, and hops flowers have been added to pillows for relief of nervous conditions.

Sedative

Hops often is included in combination with valerian in sleep aids. Observation that hops pickers experienced sedation has prompted investigation. There are no clinical studies to validate this use.

Phytoestrogenic

Estrogenic effects also were observed in evaluation of hops extract for the treatment of menstrual symptoms. There are no clinical studies to validate this use.

Other uses

Hops bitter acids have substantial effects on metabolic enzymes. A comprehensive evaluation of components of hops as a cancer chemoprentative found that it warranted clinical investigation because it had distinct activities at the initiation, promotion, and progression stages of carcinogenesis. There are no clinical studies to validate this use.

Hops bitter acids have antibacterial and antifungal activity important for the preservative function of hops in beer.

What is the recommended dosage?

Hops has been used as a mild sedative or sleep aid, with the dried strobile given in doses of 1.5 to 2 g. An extract combination with valerian, Ze 91019 (ReDormin, Ivel) has been studied at a hops dose of 60 mg for insomnia.

How safe is it?

Contraindications

Contraindications have not yet been identified.

Pregnancy/nursing

Information regarding safety and efficacy in pregnancy and lactation is lacking.

Interactions

None well documented.

Side Effects

There are no reported side effects when used in moderation.

Toxicities

As an historical food constituent, hops has “generally recognized as safe” (GRAS) status by the FDA. However, use of medicinal quantities of hops may pose more risk than common levels of exposure in food use. A wide safety margin for humans has been extrapolated from animal experiments. Malignant hyperthermic reactions have been observed in dogs that consumed boiled hops residue.

References

  1. Hops. Review of Natural Products. factsandcomparisons4.0 [online]. 2004. Available from Wolters Kluwer Health, Inc. Accessed April 17, 2007.

Copyright © 2009 Wolters Kluwer Health

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