Glycopyrrolate and neostigmine

Generic name: glycopyrrolate and neostigmine [ GLYE-koe-PIR-oh-late-and-NEE-oh-STIG-meen ]
Brand name: Prevduo
Dosage form: intravenous solution (0.6 mg-3 mg/3 mL)
Drug class: Antidotes

Medically reviewed by Drugs.com on Jan 5, 2024. Written by Cerner Multum.

What is glycopyrrolate and neostigmine?

Glycopyrrolate and neostigmine is used in adults and children at least 2 years old to regain muscle function after surgery.

Glycopyrrolate and neostigmine may also be used for purposes not listed in this medication guide.

Glycopyrrolate and neostigmine side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Glycopyrrolate and neostigmine may cause serious side effects. Call your doctor at once if you have:

• severe constipation, severe stomach pain and bloating;

• diarrhea (especially if you have a colostomy or ileostomy);

• painful or difficult urination;

• fast or pounding heartbeats, fluttering in your chest;

• confusion, severe drowsiness;

• fever, shallow breathing, weak pulse, hot and red skin; or

• eye pain, seeing halos around lights.

Common side effects of glycopyrrolate and neostigmine may include:

• nausea, vomiting;

• dry mouth;

• difficult urination or urination problems;

• blurred vision, light sensitivity;

• decreased sweating; or

• slow or fast heartbeats, fluttering in your chest.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

neostigmine, sugammadex, Bridion, Bloxiverz, glycopyrrolate / neostigmine

Warnings

Tell your doctor if you use other medicines or have other medical conditions or allergies.

Before taking this medicine

You should not use glycopyrrolate and neostigmine if you are allergic to it, or if you have:

• peritonitis (inflammation of the membrane lining the organs inside your abdomen);

• a stomach or bowel obstruction (including paralytic ileus);

• severe ulcerative colitis, toxic megacolon;

• a bladder obstruction or other urination problems;

• glaucoma;

• myasthenia gravis; or

• active bleeding with heart and blood circulation problems.

Tell your doctor if you have or have ever had:

• heart problems or a heart rhythm disorder;

• high blood pressure;

• a thyroid disorder;

• colostomy or ileostomy; or

• liver or kidney disease.

Tell your doctor if you are pregnant or breastfeeding.

How is glycopyrrolate and neostigmine given?

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Glycopyrrolate and neostigmine is injected into a vein by a healthcare provider over a period of at least 1 minute.

What happens if I miss a dose?

Glycopyrrolate and neostigmine is used as a single dose and does not have a daily dosing schedule.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving glycopyrrolate and neostigmine?

Avoid driving or hazardous activity until you know how glycopyrrolate and neostigmine will affect you. Your reactions could be impaired.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Glycopyrrolate and neostigmine can decrease sweating and you may be more prone to heat stroke.

What other drugs will affect glycopyrrolate and neostigmine?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

• medicine to treat depression, anxiety, mood disorders, or mental illness;

• bronchodilator asthma medication;

• cold or allergy medicine (Benadryl and others);

• medicine to treat overactive bladder;

• medicine to treat Parkinson's disease; or

• medicine to treat stomach problems, motion sickness, or irritable bowel syndrome.

This list is not complete and many other drugs may affect glycopyrrolate and neostigmine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2024 Cerner Multum, Inc. Version: 1.01.