Generic name: conjugated estrogens (vaginal) [ KON-joo-gay-ted-ES-troe-jenz ]
Brand names: Premarin Vaginal, Synthetic Conjugated Estrogens, A
Dosage form: vaginal cream with applicator (0.625 mg/g)
Drug classes: Estrogens, Miscellaneous vaginal agents

Medically reviewed by Drugs.com on Feb 6, 2024. Written by Cerner Multum.

What are conjugated estrogens?

Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.

Conjugated estrogens are used in the vagina to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse.

Conjugated estrogens may also be used for purposes not listed in this medication guide.

Conjugated estrogens side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Conjugated estrogens may cause serious side effects. Call your doctor at once if you have:

• heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

• signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

• signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;

• swelling or tenderness in your stomach;

• jaundice (yellowing of the skin or eyes);

• memory problems, confusion, unusual behavior;

• unusual vaginal bleeding, pelvic pain;

• a lump in your breast; or

• high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common side effects of conjugated estrogens may include:

• headache;

• pelvic pain;

• flushing (warmth, redness, or tingly feeling);

• breast pain; or

• vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

estradiol, Premarin, Estrace, Prempro, conjugated estrogens

Warnings

Do not use if you are pregnant.

You should not use conjugated estrogens if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.

Conjugated estrogens may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estrogen should not be used to prevent heart disease, stroke, or dementia.

Before taking this medicine

You should not use conjugated estrogens if you have:

• unusual vaginal bleeding that has not been checked by a doctor;

• liver disease;

• a history of heart attack, stroke, or blood clot;

• an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or

• a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.

Do not use conjugated estrogens if you are pregnant. Use effective birth control if you are not past menopause. Tell your doctor if you think you may be pregnant.

Conjugated estrogens vaginal cream can weaken the latex of a condom, diaphragm, or cervical cap. Talk to your doctor about the best birth control methods to use.

Using conjugated estrogens can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.

Estrogen should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

Tell your doctor if you have ever had:

• a hysterectomy;

• heart disease;

• liver problems, or jaundice caused by pregnancy or taking hormones;

• kidney disease;

• gallbladder disease;

• asthma;

• epilepsy or other seizure disorder;

• migraines;

• lupus;

• endometriosis or uterine fibroid tumors;

• hereditary angioedema;

• porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);

• a thyroid disorder; or

• high levels of calcium in your blood.

Using conjugated estrogens may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.

Estrogen lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding.

This medicine is not approved for use by anyone younger than 18 years old.

How should I use conjugated estrogens?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Conjugated estrogens may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using conjugated estrogens, to help lower this risk. Report any unusual vaginal bleeding right away.

Conjugated estrogens are sometimes used on a daily basis. For certain conditions, the medicine is used in a cycle, such as 3 weeks on followed by 1 week off. Follow your doctor's instructions.

To apply this medication, use only the vaginal applicator provided. After each use, take the applicator apart and clean it with mild soap and warm water. Do not use hot or boiling water.

Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.

If you need major surgery or will be on long-term bed rest, you may need to stop using conjugated estrogens for a short time. Any doctor or surgeon who treats you should know that you are using vaginal conjugated estrogens.

Store at room temperature away from moisture and heat.

Conjugated estrogens dosing information

Usual Adult Dose for Atrophic Vaginitis:

Initial dose: 0.5 grams intravaginally in a cyclic regimen: daily for 21 days, then off for 7 days
Maintenance dose: 0.5 to 2 grams intravaginally in a cyclic regimen: daily for 21 days, then off for 7 days

Comments:
-Adjust dose based on individual response

Uses: Treatment of atrophic vaginitis and kraurosis vulvae

Usual Adult Dose for Postmenopausal Symptoms:

0.5 grams intravaginally twice weekly (e.g. Monday and Thursday)
OR
0.5 grams intravaginally in a cyclic regimen: daily for 21 days, then off for 7 days

Uses: Treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, vomiting, stomach pain, breast pain, or vaginal bleeding.

What should I avoid while using conjugated estrogens?

Avoid smoking. It can greatly increase your risk of blood clots, stroke, or heart attack while using conjugated estrogens.

Grapefruit may interact with conjugated estrogens and lead to unwanted side effects. Avoid the use of grapefruit products.

What other drugs will affect conjugated estrogens?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect conjugated estrogens. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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