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Conjugated estrogens topical Pregnancy and Breastfeeding Warnings

Conjugated estrogens topical is also known as: Premarin Vaginal, Synthetic Conjugated Estrogens A

Conjugated estrogens topical Pregnancy Warnings

Conjugated estrogens have been assigned to pregnancy category X by the FDA. There are no controlled data in human pregnancy. Conjugated estrogens use is considered contraindicated during pregnancy.

An increase in the frequency of congenital malformations has been associated with use of estrogenic substances in pregnancy. Other estrogenic agents have been associated with the development of vaginal adenosis, squamous cell dysplasia of the uterine cervix and vaginal cancer later in life.

Conjugated estrogens topical Breastfeeding Warnings

There are no data on the excretion of conjugated estrogens into human milk. The American Academy of Pediatrics considers estradiol, another estrogenic agent, to be compatible with breast-feeding. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

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