Brand name: Tapazole
Drug class: Antithyroid Agents
ATC class: H03BB02
VA class: HS852
CAS number: 60-56-0

Medically reviewed by Drugs.com on Nov 15, 2023. Written by ASHP.

Introduction

Antithyroid agent;¹⁰¹ thioimidazole-derivative.^b

Uses for Methimazole

Hyperthyroidism

Used in patients with Graves’ disease with hyperthyroidism or toxic multinodular goiter for whom surgery or radioactive iodine therapy is not an appropriate treatment option.^{101 118}

Amelioration of symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy.^{101 118}

Considered drug of choice by some clinicians for virtually every patient who chooses antithyroid drug therapy for treatment of Graves’ disease, except during first trimester of pregnancy when propylthiouracil is preferred, for treatment of thyroid storm, and in patients with minor adverse reactions to methimazole who refuse radioactive iodine therapy or surgery.¹¹⁸ (See Fetal/Neonatal Morbidity and also Pregnancy under Cautions, and see Thyrotoxic Crisis under Uses.)

Preferred agent when an antithyroid drug is required for a pediatric patient because of postmarketing reports of severe liver injury in pediatric patients receiving propylthiouracil.^{101 118} (See Pediatric Use under Cautions.)

Therapy maintains patients with Graves’ disease in euthyroid state for a period of several (generally 1–2) years until spontaneous remission occurs;^{118 b} however, spontaneous remission does not occur in all patients, and most patients eventually require ablative therapy (i.e., surgery, radioactive iodine).^b Methimazole does not affect underlying cause of hyperthyroidism; minimum duration of therapy necessary before assessing whether spontaneous remission has occurred not clearly established.^b Some clinicians state that if methimazole is chosen as the primary therapy for Graves’ disease, continue the drug for approximately 12–18 months in adults or 1–2 years in children, then taper or discontinue if TSH concentrations return to normal at that time.^{118 122 123 124 125} If patients remain hyperthyroid after completing a course of methimazole, consider treatment with radioactive iodine or thyroidectomy.¹¹⁸ However, may consider treatment with low-dose methimazole for >12–18 months in adult patients not in remission who prefer this pharmacologic approach.¹¹⁸ In pediatric patients, also may continue methimazole therapy until the child is considered old enough for radioactive iodine therapy or surgery.¹¹⁸

Therapy with methimazole returns the hyperthyroid patient to a normal metabolic state prior to thyroidectomy and controls the thyrotoxic crisis that may accompany thyroidectomy.^b Some clinicians recommend that, whenever possible, adults or children with Graves’ disease undergoing thyroidectomy or adults with toxic adenoma^{† [off-label]} or toxic multinodular goiter undergoing surgery be rendered euthyroid with methimazole prior to the procedure.¹¹⁸

Therapy with methimazole controls symptoms of hyperthyroidism before and after radioactive iodine therapy until the ablative effects of iodine occur.^{118 123 129 130 131 b} However, beneficial and detrimental effects and optimal sequencing of antithyroid drugs before or after radioactive iodine therapy not clearly established.¹²⁹

Some clinicians recommend considering pretreatment with methimazole prior to radioactive iodine therapy for Graves’ disease, toxic adenoma^{† [off-label]}, or toxic multinodular goiter in adults at increased risk for complications due to worsening of hyperthyroidism (e.g., geriatric patients, patients with severe hyperthyroidism [e.g., extremely symptomatic, free thyroxine (T₄) estimates 2–3 times the ULN] or substantial comorbidities [e.g., cardiovascular disease]).¹¹⁸ However, other clinicians state pretreatment with methimazole prior to radioactive iodine therapy not necessary because there is insufficient evidence to indicate that radioactive iodine worsens hyperthyroidism, and that pretreatment with methimazole will only delay treatment with radioactive iodine.¹¹⁸ In addition, pretreatment with methimazole may reduce efficacy of subsequent radioactive iodine therapy.^{118 122 123 129 130}

Some clinicians suggest that children with Graves’ disease having total T₄ concentrations >20 mcg/dL or free T₄ estimates >5 ng/dL who are to receive radioactive iodine therapy be pretreated with methimazole and β-adrenergic blockade until total T₄ and/or free T₄ estimates normalize before proceeding with radioactive iodine.¹¹⁸

Does not induce remission in patients with nodular thyroid disease (i.e., toxic adenoma^{† [off-label]}, toxic multinodular goiter); discontinuance of therapy results in relapse.¹¹⁸ Therefore, some clinicians suggest to treat adults with overt toxic adenoma or toxic multinodular goiter with either radioactive iodine therapy or thyroidectomy, and to avoid long-term methimazole therapy.¹¹⁸ However, long-term (life-long) antithyroid drug therapy may be best choice for some geriatric or otherwise ill patients with limited longevity and increased surgical risk who can be monitored regularly (e.g., residents of nursing homes or other care facilities where compliance with radiation safety regulations may be difficult) or for patients who prefer this pharmacologic approach.¹¹⁸

Thyrotoxic Crisis

May be used for management of thyrotoxic crisis,^{118 b} although not considered antithyroid agent of first choice.^{103 118} Usually initiated before iodide (e.g., potassium iodide, strong iodine solution) therapy.^b

Related/similar drugs

propylthiouracil, Tapazole, reserpine, iodine / potassium iodide

Methimazole Dosage and Administration

General

• May use a β-adrenergic blocking agent (e.g., propranolol) concomitantly to manage peripheral signs and symptoms of hyperthyroidism, particularly cardiovascular effects (e.g., tachycardia).^b

Administration

Administer orally.¹⁰¹

Oral Administration

Manufacturer recommends administering total daily dosage usually in 3 equally divided doses at approximately 8-hour intervals.¹⁰¹ Alternatively, some clinicians state that drug may be administered as a single daily dose.¹¹⁸

Dosage

Pediatric Patients

Hyperthyroidism

Graves’ Disease with Hyperthyroidism or Toxic Multinodular Goiter

Oral

Initially, 0.4 mg/kg daily, usually given in 3 equally divided doses at approximately 8-hour intervals.¹⁰¹ Alternatively, some clinicians recommend usual dosage of 0.2–0.5 mg/kg daily (range: 0.1–1 mg/kg daily).¹¹⁸ These clinicians also suggest the following general dosages, calculated based on the patient's age and rounded to the nearest quarter-, half-, or whole-tablet dosage strengths: 1.25 mg daily for infants; 2.5–5 mg daily for children 1–5 years of age; 5–10 mg daily for children 5–10 years of age; and 10–20 mg daily for children 10–18 years of age.¹¹⁸ Patients with severe clinical or biochemical hyperthyroidism may receive dosages that are 50–100% higher than those usually recommended.¹¹⁸

Maintenance dosage: Approximately half of initial dosage or less.^{101 118}

Optimum duration of therapy not clearly established.^b However, some clinicians suggest administering drug for 1–2 years, then discontinue or reduce dosage to assess whether patient is in remission.¹¹⁸ If patient is not in remission following 1–2 years of therapy, consider treatment with radioactive iodine or thyroidectomy.¹¹⁸ Alternatively, may continue methimazole therapy for extended periods as long as adverse effects do not occur and hyperthyroidism is controlled; may use methimazole therapy as a bridge to radioactive iodine therapy or surgery at a later age if remission still has not occurred.¹¹⁸ May continue low-dose methimazole in selected situations in which radioactive iodine therapy or surgery may not be suitable or possible.¹¹⁸

Preparation for Surgical Treatment

Oral

Initially, 0.4 mg/kg daily, usually given in 3 equally divided doses at approximately 8-hour intervals.¹⁰¹

Some clinicians recommend administering methimazole usually for 1–2 months to achieve euthyroidism in preparation for thyroidectomy in patients with Graves’ disease.¹¹⁸

Preparation for Radioactive Iodine Therapy

Oral

Initially, 0.4 mg/kg daily, usually given in 3 equally divided doses at approximately 8-hour intervals.¹⁰¹

Some clinicians recommend discontinuing methimazole 3–5 days before radioactive iodine therapy.¹¹⁸ Although some clinicians restart antithyroid drugs after radioactive iodine therapy, this practice is seldom required in children.¹¹⁸

Adults

Hyperthyroidism

Graves’ Disease with Hyperthyroidism or Toxic Multinodular Goiter

Oral

Initially, 15 mg daily for mild hyperthyroidism, 30–40 mg daily for moderately severe hyperthyroidism, or 60 mg daily for severe hyperthyroidism.¹⁰¹ Alternatively, some clinicians recommend an initial dosage of 10–20 mg daily to restore euthyroidism.¹¹⁸

Considerable improvement or normal thyroid function generally achieved following 4–12 weeks of therapy, after which dosage may be decreased while maintaining normal thyroid function.^{118 122 123 124} Carefully adjust subsequent dosage according to patient’s tolerance and therapeutic response.^b (See Laboratory Monitoring under Cautions.)

Maintenance dosage: Manufacturer recommends 5–15 mg daily.¹⁰¹ Alternatively, some clinicians recommend 5–10 mg daily.¹¹⁸

Optimum duration of therapy not clearly established.^b However, some clinicians suggest continuing therapy for approximately 12–18 months, then taper or discontinue drug if TSH concentrations return to normal at that time.^{118 122 123 124 125} If patient remains hyperthyroid after completing a course of methimazole, consider treatment with radioactive iodine or thyroidectomy.¹¹⁸ However, may also consider long-term (>12–18 months) low-dose methimazole therapy in patients not in remission who prefer this pharmacologic approach.¹¹⁸

Preparation for Surgical Treatment

Oral

Initially, 15 mg daily for mild hyperthyroidism, 30–40 mg daily for moderately severe hyperthyroidism, or 60 mg daily for severe hyperthyroidism.¹⁰¹

Discontinue methimazole at time of procedure.¹¹⁸

Preparation for Radioactive Iodine Therapy

Oral

Initially, 15 mg daily for mild hyperthyroidism, 30–40 mg daily for moderately severe hyperthyroidism, or 60 mg daily for severe hyperthyroidism.¹⁰¹

Some clinicians recommend discontinuing methimazole 2–7 days before radioactive iodine; may restart methimazole 3–7 days after radioactive iodine, then generally taper over 4–6 weeks as thyroid function normalizes and radioactive iodine becomes effective.^{118 122 123 130}

Thyrotoxic Crisis

Oral

Some clinicians recommend 60–80 mg daily.¹¹⁸

Special Populations

Hepatic Impairment

No specific dosage recommendations at this time.¹⁰¹

Renal Impairment

No specific dosage recommendations at this time.¹⁰¹

Geriatric Patients

No specific dosage recommendations at this time.¹⁰¹

Pregnancy

If used during pregnancy for management of hyperthyroidism, a sufficient, but not excessive, dosage is necessary; use lowest possible dosage.¹⁰¹ Thyroid dysfunction diminishes in many women as pregnancy proceeds; may be possible to reduce antithyroid dosage, and, in some patients, may discontinue antithyroid therapy 2–3 weeks before delivery.¹⁰¹ (See Pregnancy under Cautions.)

Cautions for Methimazole

Contraindications

• Known hypersensitivity to methimazole or any ingredient in the formulation.¹⁰¹

Warnings/Precautions

Warnings

Fetal/Neonatal Morbidity

May cause fetal harm, particularly during first trimester of pregnancy.¹⁰¹ Teratogenic effects, including aplasia cutis, craniofacial malformations (facial dysmorphism, choanal atresia), and GI malformations (esophageal atresia with or without tracheoesophageal fistula, umbilical abnormalities) reported rarely in infants.¹⁰¹ May cause fetal goiter and hypothyroidism (cretinism) when administered during pregnancy.¹⁰¹

Congenital malformations reported approximately 3 times more often with prenatal exposure to methimazole compared with propylthiouracil.¹¹² Distinct and consistent pattern of congenital malformations associated with use of methimazole, but not with propylthiouracil, particularly craniofacial malformations (e.g., scalp epidermal aplasia [aplasia cutis], facial dysmorphism, choanal atresia).¹¹² Specific birth defects were associated with use of methimazole during the first trimester of pregnancy and not found when the drug was administered later in pregnancy.¹¹² FDA has not found a consistent pattern of birth defects associated with use of propylthiouracil and has concluded there is no convincing evidence of an association between propylthiouracil use and congenital malformations, even with use during the first trimester.¹¹² (See Pregnancy under Cautions and also see Distribution under Pharmacokinetics.)

Hematologic Effects

Risk of agranulocytosis;¹⁰¹ usually occurs within first 2 months of therapy, but rarely may occur after 4 months of therapy.^b May be dose related (possibly occurring more frequently with higher dosages); however, may occur irrespective of dosage, length of treatment, or previous exposure to antithyroid drug, and may occur more frequently in geriatric patients.^{118 122 123 126 127 128}

Leukopenia, thrombocytopenia, and/or aplastic anemia (pancytopenia) may occur.¹⁰¹ Hypoprothrombinemia and bleeding also may occur.¹⁰¹ (See Laboratory Monitoring under Cautions.)

Perform baseline CBC, including white count and differential, prior to initiating therapy in patients with Graves’ disease.¹¹⁸

Monitor patient carefully for signs or symptoms of illness (e.g., sore throat, skin eruptions, fever, chills, headache, general malaise), particularly during early stages of therapy.^b If fever, sore throat, or other signs or symptoms of illness occur, determine leukocyte and differential counts to assess whether agranulocytosis has developed.^{101 b}

If agranulocytosis or aplastic anemia (pancytopenia) occurs, discontinue methimazole and monitor bone marrow indices.¹⁰¹ In patients who develop agranulocytosis or other serious adverse effects while receiving methimazole or propylthiouracil, use of the other drug is contraindicated because of risk of cross-sensitivity between the two drugs.¹¹⁸

Hepatotoxicity

Hepatotoxicity (including acute liver failure) reported; risk appears to be lower with methimazole than with propylthiouracil, especially in pediatric patients.¹⁰¹ (See Pediatric Use under Cautions.)

Jaundice associated with methimazole-induced hepatitis may persist for several weeks after discontinuance of the drug.¹⁰¹

Perform liver function tests (e.g., alkaline phosphatase, aminotransferase, bilirubin) prior to initiating therapy in patients with Graves’ disease.¹¹⁸

Promptly evaluate liver function (alkaline phosphatase, bilirubin) and hepatocellular integrity (ALT, AST) if symptoms suggestive of hepatic dysfunction (e.g., anorexia, pruritus, right upper-quadrant pain) occur.¹⁰¹ If clinically relevant liver abnormality (e.g., hepatic aminotransferase concentrations >3 times the ULN) is detected, discontinue methimazole promptly.¹⁰¹ If hepatitis occurs, discontinue methimazole.¹⁰¹

Hypothyroidism

May cause hypothyroidism necessitating routine monitoring of TSH and free T₄ concentrations with dosage adjustments to maintain a euthyroid state.¹⁰¹

May cause fetal goiter and cretinism when administered to a pregnant woman, because the drug readily crosses the placenta.¹⁰¹ (See Fetal/Neonatal Morbidity and also see Pregnancy under Cautions.)

Sensitivity Reactions

Cross-sensitivity

Cross-sensitivity between thioamides may occur^{118 121} (i.e., in approximately 50% of patients switched from one thioamide agent to the other).¹²²

In patients who develop serious adverse effects (e.g., agranulocytosis) while receiving either methimazole or propylthiouracil, use of other drug also is contraindicated, because of risk of cross-sensitivity between the two drugs.¹¹⁸ In patients experiencing serious allergic reactions to methimazole, use of the alternative antithyroid drug (i.e., propylthiouracil) not recommended.¹¹⁸

General Precautions

Laboratory Monitoring

Before initiating thioamide therapy in patients with Graves’ disease, some clinicians recommend obtaining baseline free T₄ and TSH concentrations; CBC, including white count and differential; and liver function tests (e.g., alkaline phosphatase, aminotransferase, bilirubin).¹¹⁸

Monitor thyroid function (e.g., serum free T₄, serum free or total triiodothyronine [T₃], TSH) periodically (e.g., every 4–8 weeks [with subsequent dosage adjustments as needed] until thyroid function is stable or patient is euthyroid); once euthyroidism is achieved, monitor thyroid function every 2–3 months.^{101 118 122 123 124} Serum TSH not a reliable parameter to monitor early in therapy because it may remain suppressed for several months after initiation of therapy despite normalization of free T₄ concentrations.^{118 122 123 124} A suppressed TSH concentration during this period does not indicate a need for dosage increase.¹²³ However, once hyperthyroidism resolves, decrease maintenance dosage if serum TSH is elevated.^{101 123} Monitoring serum T₃ concentrations may sometimes be useful for dosage adjustment; if total or free T₃ concentrations remain elevated despite low, normal, or reduced free T₄ concentrations, may need to increase antithyroid dosage.^{122 123 124} When methimazole is discontinued in patients with Graves’ disease, monitor thyroid function every 1–3 months for 6–12 months to diagnose relapse early.¹¹⁸

Determine leukocyte and differential counts in patients who develop any signs or symptoms of illness (e.g., fever, sore throat) during therapy.^{101 b}

Monitor PT during therapy, particularly before surgical procedures, because of possible risk of hypoprothrombinemia and bleeding.¹⁰¹

Dermatologic Effects

If exfoliative dermatitis occurs, discontinue methimazole.¹⁰¹

Immunologic Effects

Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis with acute renal failure, arthritis, skin ulcerations, and a vasculitic rash reported rarely.¹²² If ANCA-positive vasculitis occurs, discontinue methimazole.¹⁰¹

Specific Populations

Pregnancy

Category D.¹⁰¹ (See Fetal/Neonatal Morbidity under Cautions and also see Distribution under Pharmacokinetics.)

Despite potential fetal hazard, antithyroid agents still considered therapy of choice for management of hyperthyroidism during pregnancy.^{108 118 119 122} Since methimazole may be associated with the rare development of fetal abnormalities (e.g., aplasia cutis, craniofacial malformations [facial dysmorphism, choanal atresia], GI malformations [esophageal atresia with or without tracheoesophageal fistula, umbilical abnormalities]),¹⁰¹ propylthiouracil is preferred when an antithyroid drug is indicated during organogenesis, in the first trimester of pregnancy, or just prior to the first trimester of pregnancy.^{100 103 106 107 108 109 118 119} (See Fetal/Neonatal Morbidity under Cautions.) Switch patients receiving methimazole to propylthiouracil if pregnancy is confirmed in first trimester.¹¹⁹ May be preferable to switch from propylthiouracil to methimazole for the second and third trimesters (i.e., after the first trimester), because of potential maternal adverse effects of propylthiouracil (e.g., hepatotoxicity).^{108 109 118 119} If switching from propylthiouracil to methimazole, assess thyroid function after 2 weeks and then every 2–4 weeks thereafter.¹⁰⁸ Not known if risk of methimazole-induced aplasia cutis or embryopathy outweighs risk of propylthiouracil-induced hepatotoxicity.¹⁰⁴

If used during pregnancy, a sufficient, but not excessive, dosage is necessary; use lowest possible dosage to control maternal disease.¹⁰¹ Initiate or adjust antithyroid drug therapy to maintain maternal free T₄ concentrations at or just above the ULN of nonpregnant reference range, or to maintain total T₄ concentrations at 1.5 times the ULN or the free T₄ index in the ULN, while using lowest possible dosage.^{108 119} Monitor free T₄ and TSH concentrations approximately every 2–6 weeks in women receiving antithyroid drugs during pregnancy.¹¹⁹ As thyroid dysfunction diminishes in many women as pregnancy proceeds, may be possible to reduce dosage of antithyroid drug; in some patients, may discontinue antithyroid drug 2–3 weeks before delivery.¹⁰¹

If used during pregnancy or if patient becomes pregnant while receiving the drug, apprise of potential hazard to the fetus; inform patient of risks of methimazole-associated fetal malformations and risks of propylthiouracil-associated hepatotoxicity when considering antithyroid drug use during pregnancy.^{101 104 106 109}

Lactation

Distributed into milk.¹⁰¹ However, no effect on clinical status and no toxicity observed in nursing infants.¹⁰¹

Generally compatible with breast-feeding; moderate dosages (i.e., 20–30 mg daily) appear to be safe.^{110 119 120 121 122} Preferred antithyroid drug in nursing women because maternal use of propylthiouracil associated with severe hepatotoxicity (i.e., hepatic necrosis in either woman or child).^{118 119} If antithyroid drug is used in nursing women, some clinicians recommend administering drug after a feeding and in divided doses, and monitoring thyroid function of nursing infants.¹¹⁹

Pediatric Use

Preferred over propylthiouracil when an antithyroid drug is required for a pediatric patient because of postmarketing reports of severe liver injury in pediatric patients receiving propylthiouracil.^{101 118} (See Hyperthyroidism under Uses.) Postmarketing cases of severe liver injury, including hepatic failure requiring liver transplantation or resulting in death, reported in pediatric patients receiving propylthiouracil; however, no such reports observed with methimazole.^{109 117} (See Hepatotoxicity under Cautions.)

Common Adverse Effects

Rash,¹⁰¹ urticaria,¹⁰¹ pruritus,¹⁰¹ skin pigmentation,¹⁰¹ abnormal hair loss,¹⁰¹ nausea,¹⁰¹ vomiting,¹⁰¹ arthralgia,¹⁰¹ myalgia,¹⁰¹ paresthesia,¹⁰¹ loss of taste,¹⁰¹ epigastric distress,¹⁰¹ edema,¹⁰¹ headache,¹⁰¹ drowsiness,¹⁰¹ neuritis,¹⁰¹ vertigo,¹⁰¹ jaundice,¹⁰¹ sialadenopathy,¹⁰¹ lymphadenopathy.¹⁰¹

Drug Interactions

Drugs Known to Cause Agranulocytosis

Use concomitantly with extreme caution.¹⁰¹ (See Hematologic Effects under Cautions.)

Specific Drugs

Methimazole Pharmacokinetics

Absorption

Bioavailability

Readily and rapidly absorbed from the GI tract following oral administration.^{101 b} Peak plasma concentrations attained within about 1 hour.^b

Distribution

Extent

Readily crosses the placenta.^{101 b}

Distributed into milk¹⁰¹ (in concentrations approximately equal to those in maternal serum).^b

Elimination

Metabolism

Metabolized in the liver.¹⁰¹

Elimination Route

Excreted in urine;^{101 b} approximately 12% of dose excreted in urine within 24 hours.^b

Half-life

5–13 hours.^b

Stability

Storage

Oral

Tablets

15–30°C.¹⁰¹

Actions

• Inhibits the synthesis of thyroid hormones¹⁰¹ by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin;^b also inhibits the coupling of these iodotyrosyl residues to form iodothyronine.^b

• Exact mechanism(s) not fully elucidated; however, methimazole may interfere with the oxidation of iodide ion and iodotyrosyl groups.^b

• Limited evidence suggests that coupling reaction is more sensitive to antithyroid agents than the iodination reaction.^b

• Does not inhibit the action of thyroid hormones already formed and present in the thyroid gland or circulation; also does not interfere with effectiveness of exogenously administered thyroid hormones.^{101 b} Patients whose thyroid gland contains a relatively high concentration of iodine (e.g., from prior ingestion, from administration during diagnostic radiologic procedures) may respond relatively slowly to antithyroid agents.^b

• Unlike propylthiouracil, does not inhibit peripheral deiodination of T₄ to triiodothyronine (T₃).^b

Advice to Patients

• Importance of informing clinicians immediately if signs or symptoms of illness (e.g., sore throat, skin eruptions, fever, chills, headache, general malaise) occur.^{101 b} Importance of immediately discontinuing the drug and contacting clinicians if signs or symptoms suggestive of agranulocytosis (e.g., fever, sore throat) occur.^{101 118} (See Hematologic Effects under Cautions.)

• Importance of immediately discontinuing the drug and promptly informing clinicians if symptoms suggestive of hepatic injury (e.g., pruritic rash, jaundice, acholic stools, dark urine, arthralgias, abdominal pain, nausea, fatigue) occur.¹¹⁸ (See Hepatotoxicity under Cautions.)

• Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.¹⁰¹

• Importance of women immediately informing clinicians if they are or plan to become pregnant or plan to breast-feed.¹⁰¹ Necessity for clinicians to advise women of methimazole-associated fetal malformations, as well as risks of propylthiouracil-associated hepatotoxicity when considering antithyroid drug use during pregnancy.^{101 104 106 109}

• Importance of informing patients of other important precautionary information.¹⁰¹ (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Frequently asked questions

• Does methimazole cause hair loss?

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