Hydrocodone Bitartrate

Pronunciation

Class: Opiate Agonists
ATC Class: R05DA03
VA Class: RE301
CAS Number: 34195-34-1
Brands: Anaplex-HD Cough, Anexsia, Ceta-Plus, Codal-DH, Codiclear DH, Codimal DH, Co-Gesic, Cyndal HD, Cytuss HC, Damason-P, Detussin, Donatussin DC, Duratuss HD, Endal HD, Entuss, Entuss-D, Entuss Expectorant, G-Tuss, Histinex HC, Histinex-D, Histussin HC, Histussin-D, Hycomine Compound, Hycosin Expectorant, Hydrogesic, Hydromet, Hydromide, Hydrophene DH, Hydro-Tussin HD, Hyphed, KG-Dal HD, KG-Dal HD Plus, KG-Tuss HD, KG-Tussin, Kwelcof, Lorcet Plus, Lortab, Maxidone Cough, Nalex DH, Norco, Pneumotussin, Protuss, Protuss-D, P-V-Tussin, Reprexain, Su-Tuss-HD, Tussafed-HC, Tuss-DS, Tussend, Tuss-HC, Tussigon, Tussionex Pennkinetic, Tuss-PD, Tuss-S Expectorant, Vanex HD, Vicodin, Vicodin ES, Vicodin Tuss Expectorant, Vicoprofen, Vitussin Expectorant, Zydone

Introduction

Opiate agonist; phenanthrene derivative.a b c

Uses for Hydrocodone Bitartrate

Pain

Symptomatic relief of moderate to moderately severe pain.a d

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Combinations of hydrocodone and NSAIAs or acetaminophen may produce additive analgesic effects because of differing mechanisms of action.c

Cough

Symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants.b

Hydrocodone Bitartrate Dosage and Administration

Administration

Oral Administration

Administer orally.a b 109

Extended-release Suspension containing Hydrocodone Polistirex and Chlorpheniramine Polistirex (Tussionex Pennkinetic)

Use a calibrated dosing device when measuring doses of the suspension.109 112 Use of a household teaspoon could result in overdosage, especially when pediatric doses (2.5 mL of suspension) are measured.109 112

Do not give more frequently than every 12 hours; if cough is not controlled, contact clinician.112

Do not dilute with fluids or mix with other drugs; shake well prior to administration.109

Dosage

Available as hydrocodone bitartrate and hydrocodone polistirex; dosage expressed in terms of hydrocodone bitartrate.a b c 109

Pediatric Patients

Cough
Hydrocodone Bitartrate
Oral

Children 6–12 years of age: 2.5 mg every 4–6 hours as needed.108

Extended-release Suspension containing Hydrocodone Polistirex and Chlorpheniramine Polistirex (Tussionex Pennkinetic)
Oral

Children 6–11 years of age: 2.5 mL (5 mg when expressed in terms of hydrocodone bitartrate) every 12 hours.109

Children ≥12 years of age: 5 mL (10 mg when expressed in terms of hydrocodone bitartrate) every 12 hours.109

Adults

Cough
Hydrocodone Bitartrate
Oral

Usual dosage is 5 mg every 4–6 hours as needed.108

Extended-release Suspension Containing Hydrocodone Polistirex and Chlorpheniramine Polistirex (Tussionex Pennkinetic)
Oral

5 mL (10 mg when expressed in terms of hydrocodone bitartrate) every 12 hours.109

Pain
Oral

5–10 mg every 4–6 hours as needed.a Adjust dosage according to severity of pain and response and tolerance of the patient.a

Nonopiate-containing analgesic fixed combinations: Nonopiate component may limit dosage of opiate component.117 119 120 121 Nonopiate analgesics are available in various fixed ratios with hydrocodone and also are available in many other prescription and OTC preparations; ensure that therapy is not duplicated and that nonopiate dosage does not exceed maximum recommended dosages.117 118 119 121

Prescribing Limits

Pediatric Patients

Cough
Hydrocodone Bitartrate
Oral

Children 6–12 years of age: Maximum is 15 mg daily.108

Extended-release Suspension Containing Hydrocodone Polistirex and Chlorpheniramine Polistirex (Tussionex Pennkinetic)
Oral

Children 6–11 years of age: Maximum 5 mL (10 mg when expressed in terms of hydrocodone bitartrate) daily.109

Children ≥12 years of age: Maximum 10 mL (20 mg when expressed in terms of hydrocodone bitartrate) daily.109

Adults

Cough
Hydrocodone Bitartrate
Oral

Maximum 30 mg daily.108

Extended-release Suspension Containing Hydrocodone Polistirex and Chlorpheniramine Polistirex (Tussionex Pennkinetic)
Oral

Maximum 10 mL (20 mg when expressed in terms of hydrocodone bitartrate) daily.109

Special Populations

Geriatric Patients

Reduce dosage in older patients.a b d 109

Cautions for Hydrocodone Bitartrate

Contraindications

  • Known hypersensitivity to hydrocodone or any ingredient in the formulation.b 109

  • Possible cross-sensitivity to hydrocodone if hypersensitive to other opiates.d

  • Extended-release oral suspension containing hydrocodone polistirex and chlorpheniramine polistirex (Tussionex Pennkinetic): Contraindicated in children <6 years of age.109

Warnings/Precautions

Warnings

Respiratory Depression

Possible dose-related respiratory depression.b c d e 109 112

Potential for increased viscosity of bronchial secretions and suppression of cough reflex, with subsequent respiratory insufficiency, in patients with asthma or pulmonary emphysema who indiscriminately use antitussives.b

Overdosage and toxicity (including fatal respiratory depression) reported in adults and children receiving the extended-release oral suspension containing hydrocodone polistirex and chlorpheniramine polistirex (Tussionex Pennkinetic).109 112 Patients should seek immediate medical assistance if they experience respiratory depression.109 112 (See Advice to Patients.)

CNS Depression

Performance of activities requiring mental alertness and physical coordination may be impaired.b c d e 109

Concurrent use of other CNS depressants may potentiate CNS depression.b d e 109 (See Specific Drugs under Interactions.)

Abuse Potential

Possible tolerance, psychologic dependence, and physical dependence following prolonged administration.b c d e 109 Use only with careful surveillance in patients with a history of drug or alcohol dependence or abuse.d e

Sensitivity Reactions

Sulfite Sensitivity

Some formulations contain sulfites, which may cause allergic-type reactions (including anaphylaxis and life-threatening or less severe asthmatic episodes) in certain susceptible individuals.b

Tartrazine Sensitivity

Some formulations may contain the dye tartrazine (FD&C yellow No. 5), which may cause allergic reactions including bronchial asthma in susceptible individuals.b Although the incidence of tartrazine sensitivity is low, it frequently occurs in patients who are sensitive to aspirin.100 101 102 103 104

General Precautions

Increased Intracranial Pressure or Head Trauma

Potential for increased respiratory depressant effects and elevation of CSF pressure in patients with increased intracranial pressure, head trauma, or other intracranial lesions.b c d e 109

Adverse effects of opiates may obscure the existence, extent, or course of intracranial pathology.b c d e 109

Acute Abdominal Conditions

Administration may complicate assessment of patients with acute abdominal conditions.d e 109 Reduce initial dosage in patients who have undergone GI surgery.

Obstructive Bowel Disease

Use may result in obstructive bowel disease, especially in patients with underlying intestinal motility disorder.109

Postoperative Patients

Suppression of cough reflex following thoracotomy or laparotomy may lead to postoperative retention of secretions; cautious use recommended.b 109

Debilitated and Special Risk Patients

Use with caution in debilitated patients and in those with hypothyroidism, Addison’s disease, prostatic hypertrophy, urethral stricture, or pulmonary disease.b c d e 109

Fixed-Combination Preparations

When used in fixed combination with other drugs, consider the cautions, precautions, and contraindications associated with the other drug(s).a

Specific Populations

Pregnancy

Category C.d e 109

Lactation

Not known whether hydrocodone is distributed into milk.d 109 Discontinue nursing or the drug.d 109

Pediatric Use

Safety and efficacy for the management of moderate to moderately severe pain has not been established.d

Safety and efficacy as an antitussive not established in children <6 years of age.105 106 107 108 109 112

Extended-release oral suspension containing hydrocodone polistirex and chlorpheniramine polistirex (Tussionex Pennkinetic): Contraindicated in children <6 years of age; use with caution in children ≥6 years of age due to the risk of respiratory depression.109 112 Risk of potentially fatal respiratory depression is increased with overdosage or concomitant use of other respiratory depressants.109 (See Warnings/Precautions and see Dosage and Administration.)

Benefit-to-risk ratio should be carefully considered, especially in children with respiratory embarrassment (e.g., croup).109

Risk of overdosage and toxicity (including death) in children <2 years of age receiving preparations containing antihistamines, cough suppressants, expectorants, and nasal decongestants alone or in combination for relief of symptoms of upper respiratory tract infection.110 111 Clinicians should ask caregivers about use of OTC cough/cold preparations to avoid overdosage.

Geriatric Use

Insufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults.d 109 Use with caution.d 109 (See Geriatric Patients under Dosage and Administration.)

Hepatic Impairment

Use with caution in severe hepatic impairment.d 109

Renal Impairment

Use with caution in severe renal impairment.d 109

Common Adverse Effects

Lightheadedness, dizziness, sedation, nausea, vomiting.b d 109 Adverse effects occur infrequently with usual oral antitussive dosages.b

Interactions for Hydrocodone Bitartrate

Specific Drugs

Drug

Interaction

Comments

Anticholinergic agents

Possible paralytic ileuse 109

Antidepressants, MAO inhibitors and tricyclics

Potentiation of antidepressant adverse effectd e 109

Use with caution; reduce dosage of hydrocodonee

CNS depressants (e.g., alcohol, antihistamines, general anesthetics, opiate agonists, phenothiazines, sedatives/hypnotics, tranquilizers)

Additive CNS effectsd 109

Reduce dosage of one or both agentsd e 109

Hydrocodone Bitartrate Pharmacokinetics

Absorption

Bioavailability

Well absorbed from the GI tract following oral administration.b

Conventional (immediate-release) preparations: Peak serum concentrations of hydrocodone occur after 1.3 hours.b d e

Extended-release oral suspension containing hydrocodone polistirex and chlorpheniramine polistirex (Tussionex Pennkinetic): Peak plasma concentrations of hydrocodone occur after 3.4 hours.109

Duration

Conventional (immediate-release) preparations: Antitussive action is maintained for 4–6 hours.b

Extended-release oral suspension containing hydrocodone polistirex and chlorpheniramine polistirex (Tussionex Pennkinetic): Symptom control maintained for up to 12 hours.109

Distribution

Extent

Distributed into skeletal muscle, kidneys, liver, intestinal tract, lungs, spleen, and brain.c

Not known whether distributed into milk.d 109

Readily crosses the placenta.c

Elimination

Metabolism

Metabolized in the liver.b

Elimination Route

Excreted mainly in the urine.b

Half-life

3.8 hours.d e 109

Stability

Storage

Oral

Tablets

Tight, light resistant containers at 15–30°C.d

Solution

Tight, light resistant containers at 15–30°C.e

Extended-release Suspension

Tussionex Pennkinetic: Tight containers at 20–25ºC (may be exposed to 15–30°C).109 Shake well before use.109

Actions

  • Principal pharmacologic effects are on CNS and intestines.c

  • Mild analgesic effect.a Acts at several sites within the CNS involving several systems of neurotransmitters to produce analgesia; precise mechanism of action not fully elucidated.c

  • Suppresses cough reflex by direct effect on cough center in medulla of brain.b 109

  • Exerts drying effect on respiratory tract mucosa and increases viscosity of bronchial secretions.b

  • Antitussive activity is slightly greater than that of codeine (on a weight basis).b

Advice to Patients

  • Importance of not exceeding the recommended dosage.109

  • Consequences of overdosage may include potentially fatal respiratory depression.109

  • Importance of seeking medical attention if trouble breathing, slow heartbeat, severe sleepiness, dizziness, confusion, or cold, clammy skin develops.109 112

  • When the extended-release oral suspension containing hydrocodone polistirex and chlorpheniramine polistirex (Tussionex Pennkinetic) is used, importance of ensuring that the correct amount of medication required for the intended dose is administered (e.g., importance of using a calibrated dosing device).109

  • Potential for drug to impair mental alertness or physical coordination; use caution when driving or operating machinery until effects on individual are known.b c d e 109

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and alcohol consumption.d e Importance of avoiding alcohol-containing beverages or products.d

  • Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.d e 109

  • Importance of advising patients of other important precautionary information.d e 109 (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Subject to control under the Federal Controlled Substances Act of 1970 as schedule III (C-III) drugs when available as a fixed-combination preparation in a concentration of ≤15 mg per dosage unit or 5 mL combined with a therapeutic amount of one or more nonopiate drugs or with a fourfold or greater quantity of isoquinolone opium alkaloid.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Hydrocodone Bitartrate Combinations

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Capsules

5 mg with Acetaminophen 500 mg*

Ceta-Plus (C-III)

Seatrace

Hydrocodone Bitartrate and Acetaminophen Capsules (C-III)

Hydrogesic (C-III)

Edwards

Solution

1.67 mg/5 mL with Chlorpheniramine Maleate 2 mg/5 mL and Phenylephrine Hydrochloride 5 mg/5 mL

Cyndal HD Syrup (C-III)

Cypress

Hydrocodone Bitartrate Chlorpheniramine Maleate and Phenylephrine Hydrochloride Liquid (C-III)

Hydrocodone HD Syrup (C-III)

Morton Grove

KG-Dal HD Syrup (C-III)

King

Tuss-PD (C-III)

Seatrace

Vanex HD (C-III)

Jones Pharma

1.67 mg/5 mL with Phenylephrine Hydrochloride 5 mg/5 mL

Nalex DH (C-III)

Blansett

1.67 mg/5 mL with Phenylephrine Hydrochloride 5 mg/5 mL and Pyrilamine Maleate 8.33 mg/5 mL

Codal-DH Syrup (C-III)

Cypress

Codimal DH Syrup (C-III)

Schwarz

Hydrophene DH Syrup (C-III)

Morton Grove

1.7 mg/5 mL with Brompheniramine Maleate 2 mg/5 mL and Pseudoephedrine Hydrochloride 30 mg/5 mL

Anaplex-HD Cough Syrup (C-III)

ECR

2 mg/5 mL with Chlorpheniramine Maleate 2 mg/5 mL and Phenylephrine Hydrochloride 5 mg/5 mL

Endal HD Syrup (C-III)

Propst

2.5 mg/5 mL with Acetaminophen 167 mg/5 mL

Hydrocodone Bitartrate and Acetaminophen Elixir (C-III)

Lortab Elixir (C-III)

UCB

2.5 mg/5 mL with Chlorpheniramine Maleate 2 mg/5 mL and Phenylephrine Hydrochloride 5 mg/5 mL

Cytuss HC Syrup (C-III)

Cypress

Histinex HC (C-III)

Ethex

Histussin HC Syrup (C-III)

Sanofi-Synthelabo

Hydrocodone CP Syrup (C-III)

KG-Dal HD Plus Syrup (C-III)

King

Tuss-HC (C-III)

Seatrace

2.5 mg/5 mL with Chlorpheniramine Maleate 2 mg/5 mL and Pseudoephedrine Hydrochloride 30 mg/5 mL

Hyphed Syrup (C-III)

Cypress

KG-Tussin Syrup (C-III)

King

P-V-Tussin Syrup (C-III)

Numark

Tussend Syrup (C-III)

Monarch

2.5 mg/5 mL with Guaifenesin 50 mg/5 mL and Phenylephrine Hydrochloride 7.5 mg/5 mL

Donatussin DC Syrup (C-III)

Laser

Tussafed-HC (C-III)

Everett

2.5 mg/5 mL with Guaifenesin 100 mg/5 mL and Pseudoephedrine Hydrochloride 30 mg/5 mL

Duratuss HD Elixir (C-III)

UCB

Hydro-Tussin HD Elixir (C-III)

Ethex

KG-Tuss HD Elixir (C-III)

King

Su-Tuss-HD Elixir (C-III)

Cypress

Tussend Expectorant (C-III)

Monarch

2.5 mg/5 mL with Guaifenesin 200 mg/5 mL

Pneumotussin 2.5 Cough Syrup (C-III)

ECR

3.5 mg/5 mL with Chlorpheniramine Maleate 2 mg/5 mL and Phenylephrine Hydrochloride 5 mg/5 mL

Endal HD Plus Syrup (C-III)

Propst

5 mg/5 mL with Chlorpheniramine Maleate 2 mg/5 mL and Phenylephrine Hydrochloride 5 mg/5 mL

Tuss-DS (C-III)

Seatrace

5 mg/5 mL with Guaifenesin 100 mg/5 mL

Codiclear DH Syrup (C-III)

Schwarz

G-Tuss Syrup (C-III)

Seatrace

Hycosin Expectorant (C-III)

Alpharma

Hydrocodone Bitartrate and Guaifenesin Expectorant (C-III)

Hydrocodone GF Syrup (C-III)

Morton Grove

Kwelcof Liquid (C-III)

Ascher

Vicodin Tuss Expectorant Syrup (C-III)

Abbott

Vitussin Expectorant (C-III)

Cypress

5 mg/5 mL with Homatropine Methylbromide 1.5 mg/5 mL

Hydrocodone Bitartrate and Homatropine Methylbromide Syrup (C-III)

Hydromet Syrup (C-III)

Alpharma

Hydromide Syrup (C-III)

Major

5 mg/5 mL with Potassium Guaiacolsulfonate 300 mg/5 mL

Entuss Expectorant (C-III)

Lee

Protuss (C-III)

First Horizon

5 mg/5 mL with Potassium Guaiacolsulfonate 300 mg/5 mL and Pseudoephedrine Hydrochloride 30 mg/5 mL

Entuss-D Liquid (C-III)

Lee

Protuss-D (C-III)

First Horizon

5 mg/5 mL with Pseudoephedrine Hydrochloride 60 mg/5 mL

Detussin Liquid (C-II)

Alpharma

Histinex-D (C-III)

Ethex

Histussin-D (C-III)

Sanofi-Synthelabo

Tuss-S Expectorant (C-III)

Seatrace

10 mg/5 mL with Potassium Guaiacolsulfonate 400 mg/5 mL

Protuss (C-III)

First Horizon

Tablets

2.5 mg with Acetaminophen 500 mg

Hydrocodone Bitartrate and Acetaminophen Tablets (C-III)

Lortab (C-III; scored)

UCB Pharma

2.5 mg with Guaifenesin 300 mg

Pneumotussin (C-III)

ECR

5 mg with Acetaminophen 250 mg, Caffeine Anhydrous 30 mg, Chlorpheniramine Maleate 2 mg, and Phenylephrine Hydrochloride 10 mg

Hycomine Compound (C-III; scored)

Endo

5 mg with Acetaminophen 400 mg*

Zydone (C-III)

Endo

5 mg with Acetaminophen 500 mg*

Anexsia 5/500 (C-III; scored)

Mallinckrodt

Co-Gesic (C-III; scored)

Schwarz

Lortab 5/500 (C-III; scored)

UCB

Vicodin (C-III; scored)

Abbott

5 mg with Aspirin 500 mg

Damason-P (C-III)

Mason

5 mg with Chlorpheniramine Maleate 4 mg and Pseudoephedrine Hydrochloride 60 mg

Tussend (C-III)

Monarch

5 mg with Guaifenesin 300 mg

Entuss (C-III)

Lee

5 mg with Homatropine Methylbromide 1.5 mg

Tussigon (C-III; scored)

Jones Pharma

5 mg with Pseudoephedrine Hydrochloride 60 mg

P-V-Tussin (C-III; scored)

Numark

7.5 mg with Acetaminophen 400 mg*

Zydone (C-III)

Endo

7.5 mg with Acetaminophen 500 mg*

Lortab (C-III; scored)

UCB

7.5 mg with Acetaminophen 650 mg*

Anexsia 7.5/650 (C-III; scored)

Mallinckrodt

Lorcet Plus (C-III; scored)

Forest

7.5 mg with Acetaminophen 750 mg*

Vicodin ES (C-III; scored)

Abbott

10 mg with Acetaminophen 325 mg

Hydrocodone Bitartrate and Acetaminophen Tablets (C-III)

Norco (C-III; scored)

Watson

10 mg with Acetaminophen 400 mg

Zydone (C-III)

Endo

10 mg with Acetaminophen 500 mg*

Lortab 10/500 (C-III; scored)

UCB

10 mg with Acetaminophen 650 mg*

Lorcet 10/650 (C-III; scored)

Forest

10 mg with Acetaminophen 660 mg

Anexia 10/660 (C-III)

Mallinckrodt

Vicodin HP (C-III; scored)

Abbott

10 mg with Acetaminophen 750 mg

Maxidone 2.5 Cough Syrup (C-III)

Watson

Tablets, film-coated

2.5 mg with Ibuprofen 200 mg

Reprexain (C-III)

Hawthorn

5 mg with Ibuprofen 200 mg

Reprexain (C-III)

Hawthorn

7.5 mg with Ibuprofen 200 mg*

Hydrocodone Bitartrate and Ibuprofen Film-coated Tablets (C-III)

Vicoprofen (C-III)

Abbott

10 mg with Ibuprofen 200 mg

Reprexain (C-III)

Hawthorn

Hydrocodone Polistirex Combinations

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Suspension, extended-release

equivalent to Hydrocodone Bitartrate 10 mg/5 mL with Chlorpheniramine Polistirex equivalent to Chlorpheniramine Maleate 8 mg/5 mL

Tussionex Pennkinetic (C-III)

UCB

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 02/2014. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Hydrocod Polst-Chlorphen Polst 10-8MG/5ML Liquid (PAR): 60/$45.99 or 120/$80.98

Hydrocodone-Acetaminophen 10-325MG Tablets (WATSON LABS): 30/$17.99 or 90/$44.97

Hydrocodone-Acetaminophen 10-500MG Tablets (MALLINCKRODT PHARM): 30/$14.99 or 90/$39.97

Hydrocodone-Acetaminophen 10-650MG Tablets (MALLINCKRODT PHARM): 30/$14.99 or 90/$30.97

Hydrocodone-Acetaminophen 10-660MG Tablets (MALLINCKRODT PHARM): 30/$17.99 or 90/$37.97

Hydrocodone-Acetaminophen 10-750MG Tablets (MALLINCKRODT PHARM): 30/$32.99 or 90/$89.97

Hydrocodone-Acetaminophen 2.5-500MG Tablets (QUALITEST): 30/$12.99 or 90/$27.27

Hydrocodone-Acetaminophen 5-325MG Tablets (MALLINCKRODT PHARM): 30/$17.99 or 60/$29.98

Hydrocodone-Acetaminophen 5-500MG Tablets (WATSON LABS): 30/$12.99 or 60/$16.98

Hydrocodone-Acetaminophen 7.5-325MG Tablets (MALLINCKRODT PHARM): 30/$17.99 or 90/$51.97

Hydrocodone-Acetaminophen 7.5-500MG/15ML Solution (QUALITEST): 473/$60.98 or 1419/$182.95

Hydrocodone-Acetaminophen 7.5-500MG Tablets (WATSON LABS): 30/$13.99 or 60/$17.98

Hydrocodone-Acetaminophen 7.5-650MG Tablets (MALLINCKRODT PHARM): 100/$15.99 or 300/$35.97

Hydrocodone-Acetaminophen 7.5-750MG Tablets (MALLINCKRODT PHARM): 30/$12.99 or 90/$23.97

Hydrocodone-Ibuprofen 7.5-200MG Tablets (AMNEAL PHARMACEUTICALS): 30/$33.99 or 90/$82.97

Lorcet 10/650 10-650MG Tablets (FOREST): 30/$57.99 or 90/$159.97

Lorcet Plus 7.5-650MG Tablets (FOREST): 30/$48.49 or 90/$131.14

Lortab 5-500MG Tablets (UCB PHARMA): 30/$57.99 or 90/$155.98

Lortab 7.5-500MG/15ML Elixir (UCB PHARMA): 120/$47.99 or 360/$119.97

Lortab 10 10-500MG Tablets (UCB PHARMA): 30/$62.99 or 90/$165.97

Lortab 2.5 2.5-500MG Tablets (UCB PHARMA): 30/$30.99 or 90/$78.97

Lortab 7.5 7.5-500MG Tablets (UCB PHARMA): 30/$64.99 or 90/$173.97

Norco 10-325MG Tablets (WATSON LABS): 30/$69.95 or 90/$204.56

Norco 5-325MG Tablets (WATSON LABS): 30/$52.65 or 90/$132.76

Norco 7.5-325MG Tablets (WATSON LABS): 30/$57.23 or 90/$160.24

Reprexain 10-200MG Tablets (HAWTHORN PHARMACEUTICALS): 100/$110.85 or 300/$313.72

Reprexain 2.5-200MG Tablets (HAWTHORN PHARMACEUTICALS): 100/$75.81 or 300/$205.77

Reprexain 5-200MG Tablets (HAWTHORN PHARMACEUTICALS): 100/$79.44 or 300/$215.31

Stagesic 5-500MG Capsules (MAGNA PHARMACEUTICALS): 30/$24.99 or 90/$51.97

Tussionex Pennkinetic ER 10-8MG/5ML Liquid (UCB PHARMA): 115/$125.99 or 345/$349.97

Tussionex Pennkinetic ER 8-10MG/5ML Liquid (UCB PHARMA): 60/$50.99 or 120/$98.97

Vicodin 5-500MG Tablets (ABBOTT): 30/$50.99 or 90/$133.97

Vicodin ES 7.5-750MG Tablets (ABBOTT): 30/$54.99 or 90/$147.97

Vicodin HP 10-660MG Tablets (ABBOTT): 30/$53.99 or 90/$145.98

Vicoprofen 7.5-200MG Tablets (ABBOTT): 30/$91.99 or 90/$249.98

Xodol 10-300MG Tablets (SHIONOGI PHARMA): 100/$583.94 or 300/$1,646.45

Zamicet 10-325MG/15ML Solution (HAWTHORN PHARMACEUTICALS): 473/$164.88 or 1419/$468.25

Zydone 10-400MG Tablets (ENDO PHARMACEUTICALS): 30/$31.99 or 90/$83.97

Zydone 5-400MG Tablets (ENDO PHARMACEUTICALS): 30/$27.99 or 90/$65.97

Zydone 7.5-400MG Tablets (ENDO PHARMACEUTICALS): 30/$32.99 or 90/$72.58

AHFS DI Essentials. © Copyright, 2004-2014, Selected Revisions February 1, 2011. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

Only references cited for selected revisions after 1984 are available electronically.

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