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Can you take antibiotics with Mavyret?

Medically reviewed by Melisa Puckey, BPharm. Last updated on July 11, 2023.

What antibiotics can you take when you have hepatitis?

Official answer

by Drugs.com

When you are taking Mavyret and need to take antibiotics you need to check:

  • if there is an interaction between the antibiotic and Mavyret
  • if there is an interaction between the antibiotic and liver disease or liver dysfunction.

If the antibiotic does not have a drug interaction with Mavyret AND it does not have a liver disease or liver impairment interaction it should be safe to take (as long as your doctor has checked for interactions with any other medicine you take and other health issues you have).

Mavyret is used to treat hepatitis C which is a viral infection that mainly affects the liver. When you have hepatitis C over time it can cause the liver to become damaged and not function properly. Some medicines, including some antibiotics, can have a bad effect on your body if your liver is impaired or damaged. This is known as a drug disease interaction. When you have hepatitis, it is important before you take any medicines, that you check the new medicine will not cause problems due to your liver issues.

Table of Mavyret Antibiotic Interactions and Liver Disease Interactions

Antibiotic
Group		 Antibiotic
Generic
Name		 Antibiotic
Brand
Name		 Mavyret
Drug
Interaction		 Liver Disease
Interaction

Penicillin class		 amoxicillin Amoxil No No
amoxicillin and clavulanate Augmentin, Augmentin ES-600, Augmentin XR No Yes, hepatotoxicity.
Major potential hazard, moderate plausibility. Applies to: liver disease.
ampicillin Unasyn No No
dicloxacillin Dynapen No No
oxacillin Bactocill No No
penicillin V potassium PC Pen VK No No
Tetracyclines demeclocycline Declomycin No Yes, hepatotoxicity.
Moderate potential hazard, moderate plausibility. Applies to: liver disease.
doxycycline Adoxa, Doryx, Doxy 100, Oracea, Vibramycin No Yes, hepatotoxicity.
moderate potential hazard, high plausibility. Applies to: liver disease, biliary obstruction.
eravacycline Xerava No No
minocycline Dynacin, Minocin, Solodyn No Yes, hepatotoxicity.
Moderate potential hazard, high plausibility. Applies to: liver disease.
omadacycline Nuzyra No No
tetracycline Panmycin, Sumycin No Yes, hepatotoxicity.
Moderate potential hazard, moderate plausibility. Applies to: liver disease.
Cephalosporins cefaclor Ceclor (brand discontinued) No Yes, liver disease.
Moderate potential hazard, moderate plausibility
cefdinir Omnicef (discontinued) No Yes, liver disease.
Moderate potential hazard, moderate plausibility
cefotaxime Claforan No Yes, Liver disease.
Moderate potential hazard, moderate plausibility.
ceftazidime Avycaz, Fortaz, Tazicef No Yes, liver disease.
Moderate potential hazard, moderate plausibility
ceftriaxone Rocephin (discontinued) No Yes, liver disease.
Moderate potential hazard, Moderate plausibility.
cefuroxime Zinacef No Yes, liver disease.
Moderate potential hazard, Moderate plausibility.
cephlexin Keflex No Yes, Liver disease.
Moderate potential hazard, moderate plausibility.
Quinolones ciprofloxacin Cipro, Cipro XR No No
levofloxacin Levaquin No No
moxifloxacin Avelox No Yes, liver disease.
Major potential hazard, moderate plausibility
Lincomycins clindamycin Cleocin, Cleocin T, Evoclin No Yes, liver disease.
Moderate potential hazard, high plausibility.
lincomycin Lincocin No Yes, liver disease.
Moderate potential hazard, high plausibility.
Macrolides azithromycin Zithromax No Yes, liver disease.
Moderate potential hazard, moderate plausibility.
clarithromycin Biaxin No No
erythromycin E.E.S., Ery-Tab, Eryc No Yes, liver disease.
Major potential hazard, moderate plausibility. Applies to: liver disease, biliary obstruction
Sulfonamides sulfamethoxazole and trimethoprim Bactrim, Bactrim DS, Septra No Yes, liver disease.
Major potential hazard, Moderate plausibility.
sulfasalazine Azulfidine No Yes, liver disease.
Major potential hazard, Moderate plausibility.
Glycopeptide Antibiotics oritavancin Orbactiv Yes, Moderate interaction Yes, hepatic impairment
Moderate potential hazard, moderate plausibility.
vancomycin Firvanq, Vancocin No No
Aminoglycosides gentamicin Garamycin (discontinued), Genoptic No No
tobramycin TOBI, Tobradex, Tobrex No No
amikacin Amikin No No
Carbapenems imipenem and cilastatin Primaxin No No
meropenem Merrem No No
ertapenem Invanz No No
Antibiotic
Generic
Name		 Antibiotic
Brand
Name		 Mavyret
Drug
Interaction		 Liver Disease
Interaction

Bottom LIne:
An antibiotic should NOT be taken with Mavyret if

  • the antibiotic has a drug interaction with Mavyret, or
  • the antibiotic has an interaction with liver disease or liver dysfunction.

Your Doctor or health professional should check for drug-drug interactions, drug-disease interactions, and be aware of any other health conditions and medicines you are on before prescribing you any medication.

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References

 

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Zithromax is not available over the counter, it is a prescription medicine that must be prescribed by a doctor. Continue reading

Some of the main differences between hepatitis B and C are:

  • Hepatitis B virus can be prevented with a vaccine, but not hepatitis C.
  • Hepatitis B and C are different viruses, but you can have both hepatitis B and hepatitis C at the same time.
  • Over 90% of people infected with hepatitis C who have not received treatment can be cured with 8 to 12 weeks of oral medications, but treatment for hepatitis B, if needed, may be long-term or lifelong.
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