Glecaprevir and pibrentasvir

Generic name: glecaprevir and pibrentasvir [ glec-A-pre-vir-and-pi-BRENT-as-vir ]
Brand name: Mavyret
Dosage forms: oral pellet (50 mg-20 mg), oral tablet (100 mg-40 mg)
Drug class: Antiviral combinations

Medically reviewed by Drugs.com on Feb 13, 2024. Written by Cerner Multum.

What is glecaprevir and pibrentasvir?

Glecaprevir and pibrentasvir is a combination antiviral medicine used to treat chronic hepatitis C in people with HCV genotype 1, 2, 3, 4, 5, or 6.

Glecaprevir and pibrentasvir is usually given after other treatments have failed.

Glecaprevir and pibrentasvir may also be used for purposes not listed in this medication guide.

Glecaprevir and pibrentasvir side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, glecaprevir and pibrentasvir may cause serious liver injury. Tell your doctor right away if you have symptoms such as:

• right-sided upper stomach pain;

• nausea, vomiting, loss of appetite;

• confusion, tiredness, feeling light-headed;

• easy bruising or bleeding, vomiting blood;

• diarrhea, black or bloody stools;

• dark urine; or

• yellowing of your skin or eyes.

Common side effects of glecaprevir and pibrentasvir may include:

• headache; or

• tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use glecaprevir and pibrentasvir if you have severe liver disease, or if you also take atazanavir or rifampin.

If you've ever had hepatitis B, it may become active or get worse after you stop using glecaprevir and pibrentasvir. You may need frequent liver function tests for several months.

Before taking this medicine

You should not use this medicine if you are allergic to glecaprevir or pibrentasvir, or if:

• you have liver disease; or

• you also take atazanavir or rifampin.

Tell your doctor if you have ever had:

• hepatitis B;

• liver problems other than hepatitis;

• a liver or kidney transplant;

• HIV (human immunodeficiency virus); or

• an opioid addiction or past use of injected drugs.

Tell your doctor if you are pregnant or breastfeeding.

Glecaprevir and pibrentasvir should not be given to a child younger than 3 years old.

How should I take glecaprevir and pibrentasvir?

Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using glecaprevir and pibrentasvir.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

You should not stop using glecaprevir and pibrentasvir suddenly. Stopping suddenly could make your condition harder to treat with hepatitis C antiviral medicine.

Use all hepatitis C medications as directed and read all medication guides you receive. Do not change your dose or stop using a medicine without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor.

If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using glecaprevir and pibrentasvir. You may need frequent liver function tests while using glecaprevir and pibrentasvir and for several months after your last dose.

Store this medicine in the original container at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 18 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking glecaprevir and pibrentasvir?

Using glecaprevir and pibrentasvir will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What other drugs will affect glecaprevir and pibrentasvir?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Other drugs can affect glecaprevir and pibrentasvir, and some drugs should not be used at the same time. Tell your doctor about all other medicines you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Popular FAQ

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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