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Drug Interaction Report

1 potential interaction and/or warning found for the following 2 drugs:

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Interactions between your drugs

Moderate

tobramycin neomycin topical

Applies to: Nebcin Pediatric (tobramycin), bacitracin / neomycin / polymyxin b / pramoxine topical

Both neomycin topical and tobramycin belong to the same class of antibiotics known as aminoglycosides. Since the medication in neomycin topical may be absorbed from the skin, combining it with tobramycin may increase the risk of serious side effects reported with aminoglycosides such as hearing loss, respiratory depression, and kidney problems. Patients who may be particularly susceptible include the elderly and those who are dehydrated or have preexisting kidney disease. Neomycin topical should generally not be used with tobramycin in circumstances where significant absorption could occur (for example: application to burnt or broken skin; use of large quantities or on large areas for prolonged periods). Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Let your doctor know immediately if you experience hearing loss, ringing in the ears, vertigo, difficulty breathing, or signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.