Drug Interaction Report
40 potential interactions and/or warnings found for the following 11 drugs:
- albuterol
- beclomethasone
- fluticasone
- formoterol
- ipratropium
- ketoconazole
- montelukast
- prednisolone
- salmeterol
- terbutaline
- theophylline
Interactions between your drugs
ketoconazole salmeterol
Applies to: ketoconazole, salmeterol
Ketoconazole may significantly increase the blood levels of salmeterol following oral inhalation. High blood levels of salmeterol can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
ketoconazole fluticasone
Applies to: ketoconazole, fluticasone
Ketoconazole may significantly increase the absorption of fluticasone into the blood stream. You may be more likely to experience side effects such as swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. Children may experience a reduced growth rate due to excessive effects of fluticasone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
prednisoLONE theophylline
Applies to: prednisolone, theophylline
Using theophylline together with prednisoLONE may cause hypokalemia (low blood potassium) and increased theophylline levels. Contact your doctor if you experience weakness, listlessness, confusion, tingling of the extremities, or feelings of heaviness in the legs. Signs and symptoms of too much theophylline include nausea, vomiting, diarrhea, headache, restlessness, insomnia, and irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
salmeterol formoterol
Applies to: salmeterol, formoterol
Using salmeterol together with formoterol may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
terbutaline formoterol
Applies to: terbutaline, formoterol
Using terbutaline together with formoterol may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
albuterol formoterol
Applies to: albuterol, formoterol
Using albuterol together with formoterol may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
theophylline formoterol
Applies to: theophylline, formoterol
Using theophylline together with formoterol may increase cardiovascular side effects such as heart palpitations, increased heart and pulse rates, and blood pressure elevations. Combining these medications may also increase the risk of developing hypokalemia, or low blood potassium. Although the hypokalemia associated with these drugs is generally mild and does not cause problems, severe cases can occasionally lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. Side effects may be more likely if you are receiving formoterol or similar medications in the nebulized, oral, or injectable form. In addition, these medications given orally or by injection may sometimes reduce the blood levels and effects of theophylline. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your breathing worsens or you experience nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness, tingling, rapid heartbeat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
ketoconazole formoterol
Applies to: ketoconazole, formoterol
Using formoterol together with ketoconazole can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). The risk may exist even when formoterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Do not exceed the dose and frequency of use recommended on the product label or prescribed by your doctor. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
terbutaline salmeterol
Applies to: terbutaline, salmeterol
Using terbutaline together with salmeterol may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
albuterol salmeterol
Applies to: albuterol, salmeterol
Using albuterol together with salmeterol may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
theophylline salmeterol
Applies to: theophylline, salmeterol
Using theophylline together with salmeterol may increase cardiovascular side effects such as heart palpitations, increased heart and pulse rates, and blood pressure elevations. Combining these medications may also increase the risk of developing hypokalemia, or low blood potassium. Although the hypokalemia associated with these drugs is generally mild and does not cause problems, severe cases can occasionally lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. Side effects may be more likely if you are receiving salmeterol or similar medications in the nebulized, oral, or injectable form. In addition, these medications given orally or by injection may sometimes reduce the blood levels and effects of theophylline. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your breathing worsens or you experience nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness, tingling, rapid heartbeat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
prednisoLONE ketoconazole
Applies to: prednisolone, ketoconazole
Ketoconazole may increase the blood levels of prednisoLONE. You may be more likely to experience side effects such as swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. Children may experience a reduced growth rate due to excessive effects of prednisoLONE. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
albuterol terbutaline
Applies to: albuterol, terbutaline
Using albuterol together with terbutaline may increase cardiovascular side effects such as elevations in heart rate and blood pressure or irregular heart rhythm. Talk to your doctor if you have any questions or concerns, particularly if you have a history of high blood pressure, arrhythmia, or heart disease. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
theophylline terbutaline
Applies to: theophylline, terbutaline
Using theophylline together with terbutaline may increase cardiovascular side effects such as heart palpitations, increased heart and pulse rates, and blood pressure elevations. Combining these medications may also increase the risk of developing hypokalemia, or low blood potassium. Although the hypokalemia associated with these drugs is generally mild and does not cause problems, severe cases can occasionally lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. Side effects may be more likely if you are receiving terbutaline or similar medications in the nebulized, oral, or injectable form. In addition, these medications given orally or by injection may sometimes reduce the blood levels and effects of theophylline. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your breathing worsens or you experience nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness, tingling, rapid heartbeat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
ketoconazole terbutaline
Applies to: ketoconazole, terbutaline
Using terbutaline together with ketoconazole can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). The risk may exist even when terbutaline or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Do not exceed the dose and frequency of use recommended on the product label or prescribed by your doctor. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
ketoconazole albuterol
Applies to: ketoconazole, albuterol
Using albuterol together with ketoconazole can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). The risk may exist even when albuterol or similar medications are given by oral inhalation directly into the lungs, and more so if these products are overused. Do not exceed the dose and frequency of use recommended on the product label or prescribed by your doctor. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
theophylline albuterol
Applies to: theophylline, albuterol
Using theophylline together with albuterol may increase cardiovascular side effects such as heart palpitations, increased heart and pulse rates, and blood pressure elevations. Combining these medications may also increase the risk of developing hypokalemia, or low blood potassium. Although the hypokalemia associated with these drugs is generally mild and does not cause problems, severe cases can occasionally lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. Side effects may be more likely if you are receiving albuterol or similar medications in the nebulized, oral, or injectable form. In addition, these medications given orally or by injection may sometimes reduce the blood levels and effects of theophylline. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your breathing worsens or you experience nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness, tingling, rapid heartbeat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of hypokalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
beclomethasone salmeterol
Applies to: beclomethasone, salmeterol
Information for this minor interaction is available on the professional version.
fluticasone formoterol
Applies to: fluticasone, formoterol
Information for this minor interaction is available on the professional version.
beclomethasone formoterol
Applies to: beclomethasone, formoterol
Information for this minor interaction is available on the professional version.
ketoconazole theophylline
Applies to: ketoconazole, theophylline
Information for this minor interaction is available on the professional version.
prednisoLONE albuterol
Applies to: prednisolone, albuterol
Information for this minor interaction is available on the professional version.
prednisoLONE formoterol
Applies to: prednisolone, formoterol
Information for this minor interaction is available on the professional version.
fluticasone salmeterol
Applies to: fluticasone, salmeterol
Information for this minor interaction is available on the professional version.
terbutaline beclomethasone
Applies to: terbutaline, beclomethasone
Information for this minor interaction is available on the professional version.
prednisoLONE terbutaline
Applies to: prednisolone, terbutaline
Information for this minor interaction is available on the professional version.
prednisoLONE salmeterol
Applies to: prednisolone, salmeterol
Information for this minor interaction is available on the professional version.
terbutaline fluticasone
Applies to: terbutaline, fluticasone
Information for this minor interaction is available on the professional version.
albuterol fluticasone
Applies to: albuterol, fluticasone
Information for this minor interaction is available on the professional version.
albuterol beclomethasone
Applies to: albuterol, beclomethasone
Information for this minor interaction is available on the professional version.
No other interactions were found between your selected drugs. However, this does not necessarily mean no other interactions exist. Always consult your healthcare provider.
Drug and food interactions
ketoconazole food
Applies to: ketoconazole
You should avoid the use of alcohol while being treated with ketoconazole. Ketoconazole may cause liver damage and using it with alcohol or products containing alcohol may increase that risk. In addition, consumption of alcoholic beverages or products containing alcohol during treatment with ketoconazole may trigger a disulfiram-like reaction in some patients, with unpleasant symptoms such as flushing, palpitations, and nausea. Ketoconazole may be taken with or without food. You should avoid consumption of grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with ketoconazole unless directed otherwise by your doctor. Grapefruit juice may increase the blood levels of ketoconazole. This may increase the risk and/or severity of side effects and liver problems. You should seek immediate medical attention if you develop signs and symptoms of liver damage during treatment with ketoconazole, such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
theophylline food
Applies to: theophylline
Both smoking and excessive caffeine consumption can alter the blood levels of theophylline, which may affect the dosing. Tobacco and marijuana smoke (including secondhand exposure) generally reduces, while caffeine increases, blood levels. In addition, caffeine is a stimulant and may add to the side effects of theophylline such as headache, insomnia, and increases in blood pressure and heart rate. It is best to avoid smoking and to limit caffeine consumption during theophylline therapy. Talk to a healthcare professional if you have any questions or concerns. If you start smoking or undergo smoking cessation, your doctor may need to monitor your blood levels more closely to determine if you need a dose adjustment of theophylline. You should stop taking theophylline and seek medical attention if you experience potential signs and symptoms of excessive drug levels such as nausea, vomiting, persistent headache, insomnia, and rapid heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
When theophylline is given with enteral (tube) feedings, blood levels may be decreased due to interference with its absorption. This may reduce the effectiveness of the medication. To minimize potential for interaction, you may interrupt the feeding for one hour before and one hour after the theophylline dose. You may need more frequent blood tests to monitor theophylline levels.
theophylline food
Applies to: theophylline
Ask your doctor before using theophylline together with caffeine. Using these medications together may increase some of the side effects of theophylline. This can cause nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). Avoid drinks or foods that contain caffeine, such as coffee, tea, cola, and chocolate. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
albuterol food
Applies to: albuterol
Both albuterol and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
terbutaline food
Applies to: terbutaline
Both terbutaline and caffeine can increase blood pressure and heart rate, and combining them may enhance these effects. Talk to your doctor before using these medications, especially if you have a history of high blood pressure or heart disease. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Autonomic drugs
Therapeutic duplication
The recommended maximum number of medicines in the 'autonomic drugs' category to be taken concurrently is usually three. Your list includes seven medicines belonging to the 'autonomic drugs' category:
- albuterol
- formoterol
- ipratropium
- montelukast
- salmeterol
- terbutaline
- theophylline
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Adrenal hormones
Therapeutic duplication
The recommended maximum number of medicines in the 'adrenal hormones' category to be taken concurrently is usually two. Your list includes three medicines belonging to the 'adrenal hormones' category:
- beclomethasone
- fluticasone
- prednisolone
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Cortisones
Therapeutic duplication
The recommended maximum number of medicines in the 'cortisones' category to be taken concurrently is usually one. Your list includes three medicines belonging to the 'cortisones' category:
- beclomethasone
- fluticasone
- prednisolone
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Bronchodilators
Therapeutic duplication
The recommended maximum number of medicines in the 'bronchodilators' category to be taken concurrently is usually two. Your list includes six medicines belonging to the 'bronchodilators' category:
- albuterol
- formoterol
- montelukast
- salmeterol
- terbutaline
- theophylline
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Inhaled smooth muscle relaxants
Therapeutic duplication
The recommended maximum number of medicines in the 'inhaled smooth muscle relaxants' category to be taken concurrently is usually one. Your list includes four medicines belonging to the 'inhaled smooth muscle relaxants' category:
- albuterol
- formoterol
- salmeterol
- terbutaline
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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