Excipient (pharmacologically inactive substance)
What is Pregelatinized Starch?
Starches are typically derived from corn or potato. Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule disintegrant, a glidant, or as binder. Disintegrants enable tablets and capsules to break down into smaller fragments (dissolve) so that the drug can be released for absorption. Starches also absorb water rapidly, allowing tablets to disintegrate appropriately.
Starches are also used in the food manufacturing industry for processing, and as food thickeners or stabilizers. There are many other diverse uses for starches in the manufacturing industry. Pregelatinized starch derives primarily from corn, has been cooked and then dried. Instant puddings, pie fillings, soup mixes, salad dressings, candy often contain pregelatinized starch.
Pregelatinized starches (dried, cooked starches) are highly digestible. Consumption of excessive quantities of raw starch has resulted in obesity and iron-deficiency anemia in humans. However, there is no evidence to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
Top Medications Containing Pregelatinized Starch
- Acetaminophen and Hydrocodone Bitartrate 500 mg / 5 mg (Ranbaxy Pharmaceuticals Inc.)
- Acyclovir 400 mg (Ranbaxy Pharmaceuticals Inc.)
- Atropine Sulfate and Diphenoxylate Hydrochloride 0.025 mg / 2.5 mg (Sandoz Pharmaceuticals Inc.)
- Baclofen 10 mg (Caraco Pharmaceutical Laboratories)
- Bextra 20 mg (G.D. Searle LLC)
- Bextra 10 mg (G.D. Searle LLC)
- Furosemide 40 mg (Roxane Laboratories, Inc.)
- Furosemide 20 mg (Roxane Laboratories, Inc.)
- Furosemide 80 mg (Roxane Laboratories, Inc.)
- Hydrochlorothiazide 25 mg (Actavis)
- LORTAB 2.5/500 500 mg / 2.5 mg (UCB Pharma, Inc.)
- Lovastatin 40 mg (Actavis)
- Meperidine Hydrochloride 100 mg (Mallinckrodt Pharmaceuticals)
- Methadone HCl Diskets 40 mg (Cebert Pharmaceuticals Inc)
- Mirtazapine 15 mg (Caraco Pharmaceutical Laboratories)
- Talacen 650 mg / 25 mg (Sanofi-Aventis)
- Topiramate 25 mg (Ranbaxy Pharmaceuticals Inc.)
- Tramadol Hydrochloride 50 mg (Akyma Pharmaceuticals)
- Tramadol Hydrochloride 50 mg (Watson Pharmaceuticals)
- VISKEN 10 MG (Novartis Pharmaceuticals)