Kisqali and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Kisqali (ribociclib).
Ribociclib Food
Moderate Food Interaction
GENERALLY AVOID: Pomegranates and grapefruit may increase the systemic exposure to ribociclib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in these fruits. Increased exposure to ribociclib may increase the risk of adverse effects such as infections, neutropenia, leukopenia, anemia, thrombocytopenia, anorexia, nausea, vomiting, diarrhea, stomatitis, alopecia, fatigue, headache, and abnormal liver function may be increased.
MANAGEMENT: Patients receiving ribociclib should avoid consumption of pomegranates or pomegranate juice and grapefruit or grapefruit juice during treatment.
References
- (2017) "Product Information. Kisqali (ribociclib)." Novartis Pharmaceuticals
Kisqali drug interactions
There are 708 drug interactions with Kisqali (ribociclib).
Kisqali disease interactions
There are 6 disease interactions with Kisqali (ribociclib) which include:
- Ribociclib – arrhythmias
- lung toxicity
- cutaneous toxicity
- hepatic impairment
- neutropenia
- renal impairment
More about Kisqali (ribociclib)
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- During pregnancy
- FDA approval history
- Drug class: CDK 4/6 inhibitors
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.