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Pralsetinib and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with pralsetinib.

Major

Pralsetinib Food

Major Food Interaction

Pralsetinib should be taken on an empty stomach, at least 2 hours after or 1 hour before a meal. Do not consume grapefruit, grapefruit juice, or any supplements that contain grapefruit extract during treatment with pralsetinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of pralsetinib. This may increase the risk and/or severity of serious side effects such as lung problems, high blood pressure, liver problems, bleeding, fatigue, muscle pains, or constipation. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

Pralsetinib High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

pralsetinib - hypertension

Hypertension has been reported in patients in treatment with pralsetinib. This drug should not be initiated in patients with uncontrolled hypertension. Caution and close monitoring is advised.

References

  1. (2020) "Product Information. Gavreto (pralsetinib)." Blueprint Medicines Corporation

Pralsetinib drug interactions

There are 680 drug interactions with pralsetinib.

Pralsetinib disease interactions

There are 4 disease interactions with pralsetinib which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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