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Pralsetinib Disease Interactions

There are 4 disease interactions with pralsetinib.

Moderate

Pralsetinib (applies to pralsetinib) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Pralsetinib has not been studied in patients with moderate or severe hepatic impairment. Additionally, clinical trials reported hepatotoxicity in some patients receiving treatment. Caution and close monitoring is advised if administering in patients with hepatic impairment.

References

  1. (2020) "Product Information. Gavreto (pralsetinib)." Blueprint Medicines Corporation
Moderate

Pralsetinib (applies to pralsetinib) hypertension

Moderate Potential Hazard, Moderate plausibility.

Hypertension has been reported in patients in treatment with pralsetinib. This drug should not be initiated in patients with uncontrolled hypertension. Caution and close monitoring is advised.

References

  1. (2020) "Product Information. Gavreto (pralsetinib)." Blueprint Medicines Corporation
Moderate

Pralsetinib (applies to pralsetinib) QT prolongation

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Long QT Syndrome, Hypokalemia, Magnesium Imbalance, Hypocalcemia

QT prolongation was reported in clinical trials in patients that received pralsetinib. Use with caution in patients with history of arrhythmias, QT prolongation or taking medications that can prolong the QT interval (e.g., strong CYP450 3A4 inhibitors). Monitor QT interval and serum electrolytes before initiation and regularly during treatment. Hypokalemia, hypomagnesemia, and hypocalcemia should be corrected prior and during treatment.

References

  1. (2020) "Product Information. Gavreto (pralsetinib)." Blueprint Medicines Corporation
Moderate

Pralsetinib (applies to pralsetinib) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Pralsetinib has not been studied in patients with severe renal impairment or end-stage renal disease. Caution is advised if administering in these patients.

References

  1. (2020) "Product Information. Gavreto (pralsetinib)." Blueprint Medicines Corporation

Pralsetinib drug interactions

There are 680 drug interactions with pralsetinib.

Pralsetinib alcohol/food interactions

There are 2 alcohol/food interactions with pralsetinib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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