Phenobarbital Alcohol, Food & Lifestyle Interactions

There are 2 food and lifestyle interactions with phenobarbital which include:

GENERALLY AVOID: Concurrent acute use of barbiturates and ethanol may result in additive CNS effects, including impaired coordination, sedation, and death. Tolerance of these agents may occur with chronic use. The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.

MANAGEMENT: The combination of ethanol and barbiturates should be avoided.

barbiturates IV - cardiovascular

The intravenous administration of barbiturates may produce severe cardiovascular reactions such as bradycardia, hypertension, or vasodilation with fall in blood pressure, particularly during rapid infusion. Parenteral therapy with barbiturates should be administered cautiously in patients with hypertension, hypotension, or cardiac disease. The intravenous administration of barbiturates should be reserved for emergency treatment of acute seizures or for anesthesia.

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phenobarbital drug Interactions

There are 800 drug interactions with phenobarbital

phenobarbital disease Interactions

There are 14 disease interactions with phenobarbital which include:

Acute Alcohol Intoxication Drug Dependence Liver Disease Porphyria Rash Respiratory Depression Cardiovascular

Prolonged Hypotension Renal Dysfunction Adrenal Insufficiency Depression Hematologic Toxicity Osteomalacia Paradoxical Reactions

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