Skip to main content

Naproxen and Alcohol/Food Interactions

There are 4 alcohol/food/lifestyle interactions with naproxen.

Moderate

naproxen Alcohol (Ethanol)

Moderate Drug Interaction

Ask your doctor before using naproxen together with ethanol. Do not drink alcohol while taking naproxen. Alcohol can increase your risk of stomach bleeding caused by naproxen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Major

High Blood Pressure (Hypertension)

Major Potential Hazard, Moderate plausibility

NSAIDs - fluid retention

Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.

References

  1. "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn PROD (2002):
  2. "Product Information. Nalfon (fenoprofen)." Xspire Pharma PROD (2002):
  3. "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
  4. "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories PROD (2002):
  5. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
  6. "Product Information. Anaprox (naproxen)." Roche Laboratories PROD (2006):
  7. "Product Information. Clinoril (sulindac)." Merck & Co., Inc PROD (2001):
  8. "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical PROD (2001):
  9. "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
  10. "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
  11. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
  12. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
  13. "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
  14. "Product Information. Mobic (meloxicam)." Boehringer-Ingelheim PROD (2001):
View all 14 references
Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

naproxen - sodium

Anaprox and Anaprox DS (brands of naproxen sodium) contain 25 mg and 50 mg of sodium per tablet (approximately 1 mEq/250 mg naproxen), respectively, and Naprosyn suspension contains 39 mg per teaspoonful (approximately 1.5 mEq/125 mg naproxen). The sodium content should be considered when these products are used in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.

References

  1. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
  2. "Product Information. Anaprox (naproxen)." Roche Laboratories PROD (2006):
Moderate

High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

NSAIDs - hypertension

Nonsteroidal anti-inflammatory drugs (NSAIDs), including topicals, can lead to new onset of hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. NSAIDs should be used with caution in patients with hypertension. Blood pressure should be monitored closely during the initiation of NSAID therapy and throughout the course of therapy.

References

  1. "Product Information. Indocin (indomethacin)." Merck & Co., Inc PROD (2002):
  2. "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc PROD (2002):
  3. "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals PROD (2001):
  4. "Product Information. Relafen (nabumetone)." SmithKline Beecham PROD (2001):
  5. "Product Information. Feldene (piroxicam)." Pfizer U.S. Pharmaceuticals PROD (2001):
  6. "Product Information. Dolobid (diflunisal)." Merck & Co., Inc PROD (2001):
  7. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn PROD (2001):
  8. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories PROD (2001):
  9. "Product Information. Daypro (oxaprozin)." Searle PROD (2001):
  10. "Product Information. Celebrex (celecoxib)." Searle PROD (2001):
  11. "Product Information. Meclofenamate Sodium (meclofenamate)." Mylan Pharmaceuticals Inc (2012):
  12. "Product Information. Flector Patch (diclofenac topical)." Actavis U.S. (Alpharma USPD) (2016):
View all 12 references

Naproxen drug interactions

There are 424 drug interactions with naproxen.

Naproxen disease interactions

There are 13 disease interactions with naproxen which include:


Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.