Vicodin (acetaminophen/hydrocodone) Alcohol, Food & Lifestyle Interactions

There is 1 food and lifestyle interaction with Vicodin (acetaminophen/hydrocodone):

GENERALLY AVOID: Chronic, excessive consumption of alcohol may increase the risk of acetaminophen-induced hepatotoxicity, which has included rare cases of fatal hepatitis and frank hepatic failure requiring liver transplantation. The proposed mechanism is induction of hepatic microsomal enzymes during chronic alcohol use, which may result in accelerated metabolism of acetaminophen and increased production of potentially hepatotoxic metabolites.

MANAGEMENT: In general, chronic alcoholics should avoid regular or excessive use of acetaminophen. Alternative analgesic/antipyretic therapy may be appropriate in patients who consume three or more alcoholic drinks per day. However, if acetaminophen is used, these patients should be cautioned not to exceed the recommended dosage (maximum 4 g/day in adults and children 12 years of age or older).

GENERALLY AVOID: The central nervous system-depressant effects of opioid analgesics and ethanol may be additive. The combination of these agents may result in additive CNS-depression and impairment of judgment, thinking, and psychomotor skills. In more severe cases, respiratory depression, hypotension, profound sedation, and coma can occur. Death has been reported in overdosage.

MANAGEMENT: The concomitant use of opioid analgesics and ethanol should be avoided.

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Vicodin (acetaminophen/hydrocodone) drug Interactions

There are 530 drug interactions with Vicodin (acetaminophen/hydrocodone)

Vicodin (acetaminophen/hydrocodone) disease Interactions

There are 19 disease interactions with Vicodin (acetaminophen/hydrocodone) which include:

Alcoholism Liver Disease Impaired Gi Motility Infectious Diarrhea Liver Disease Prematurity Renal Dysfunction Acute Alcohol Intoxication Drug Dependence Hypotension

Intracranial Pressure Respiratory Depression Pku Adrenal Insufficiency Biliary Spasm Hypothyroidism Seizure Disorders Urinary Retention Arrhythmias

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