Skip to main content

Drug Interactions between ticlopidine and tirofiban

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Major

ticlopidine tirofiban

Applies to: ticlopidine and tirofiban

MONITOR CLOSELY: The combination of glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors and other drugs that inhibit platelet aggregation may significantly increase the risk of bleeding, especially from arterial puncture sites. The mechanism is synergistic pharmacologic effects. However, in a phase 3 clinical trial (TRITON-TIMI 38) evaluating the safety and efficacy of prasugrel and clopidogrel in patients with acute coronary syndrome (ACS) undergoing percutaneous intervention (PCI), the use of a GP IIb/IIIa inhibitor (type used not uniformly captured in the study) did not increase the relative risk of bleeding with prasugrel as compared with clopidogrel when the thienopyridine loading dose was administered shortly before or at the time of PCI.

MANAGEMENT: Extraordinary precautions are recommended if these drugs must be used together, including monitoring platelet counts and hemoglobin concentrations. In addition, invasive procedures, such as urinary catheterization, nasogastric or nasotracheal intubation, and even venous punctures should be avoided or minimized. Non-compressible venous access sites, such as jugular or subclavian sites, should be avoided.

References

  1. "Product Information. ReoPro (abciximab)." Lilly, Eli and Company PROD (2001):
  2. "Product Information. Integrilin (eptifibatide)." Schering Corporation PROD (2001):
  3. Klinkhardt U, Kirchmaier CM, Westrup D, Graff J, Mahnel R, Breddin HK, Harder S "Ex vivo-in vitro interaction between aspirin, clopidogrel, and the glycoprotein IIb/IIIa inhibitors abciximab and SR121566A." Clin Pharmacol Ther 67 (2000): 305-13
  4. O'Donoghue M, Antman EM, Braunwald E, et al. "The efficacy and safety of prasugrel with and without a glycoprotein IIb/IIIa inhibitor in patients with acute coronary syndromes undergoing percutaneous intervention: a TRITON-TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Pla" J Am Coll Cardiol 54 (2009): 678-85
View all 4 references

Switch to consumer interaction data

Drug and food interactions

Moderate

ticlopidine food

Applies to: ticlopidine

ADJUST DOSING INTERVAL: The bioavailability and gastrointestinal tolerance of ticlopidine is enhanced by food.

MANAGEMENT: Patients may be advised to take ticlopidine with meals.

References

  1. "Product Information. Ticlid (ticlopidine)." Syntex Laboratories Inc PROD (2001):

Switch to consumer interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer