Drug Interactions between ranitidine and Unasyn
This report displays the potential drug interactions for the following 2 drugs:
- ranitidine
- Unasyn (ampicillin/sulbactam)
Interactions between your drugs
No interactions were found between ranitidine and Unasyn. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
ranitidine
A total of 139 drugs are known to interact with ranitidine.
- Ranitidine is in the drug class H2 antagonists.
-
Ranitidine is used to treat the following conditions:
- Cutaneous Mastocytosis
- Duodenal Ulcer
- Duodenal Ulcer Prophylaxis
- Eczema (off-label)
- Erosive Esophagitis
- Gastric Ulcer Maintenance Treatment
- Gastrointestinal Hemorrhage
- GERD
- Hiatal Hernia (off-label)
- Indigestion
- Laryngopharyngeal Reflux (off-label)
- Pathological Hypersecretory Conditions
- Stomach Ulcer
- Stress Ulcer Prophylaxis
- Surgical Prophylaxis
- Urticaria (off-label)
- Zollinger-Ellison Syndrome
Unasyn
A total of 58 drugs are known to interact with Unasyn.
- Unasyn is in the drug class beta-lactamase inhibitors.
-
Unasyn is used to treat the following conditions:
- Aspiration Pneumonia
- Bacterial Infection
- Bone infection
- Deep Neck Infection
- Endocarditis
- Epiglottitis
- Intraabdominal Infection
- Joint Infection
- Kidney Infections
- Meningitis
- Pelvic Inflammatory Disease
- Peritonitis
- Pneumonia
- Sinusitis
- Skin and Structure Infection
- Skin or Soft Tissue Infection
- Surgical Prophylaxis
- Urinary Tract Infection
Drug and food interactions
ampicillin food
Applies to: Unasyn (ampicillin / sulbactam)
ADJUST DOSING INTERVAL: Certain penicillins may exhibit reduced gastrointestinal absorption in the presence of food. The therapeutic effect of the antimicrobial may be reduced.
MANAGEMENT: The interacting penicillin should be administered one hour before or two hours after meals. Penicillin V and amoxicillin are not affected by food and may be given without regard to meals.
References
- Neu HC "Antimicrobial activity and human pharmacology of amoxicillin." J Infect Dis 129 (1974): s123-31
- Welling PG, Huang H, Koch PA, Madsen PO "Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects." J Pharm Sci 66 (1977): 549-52
- McCarthy CG, Finland M "Absorption and excretion of four penicillins." N Engl J Med 263 (1960): 315-26
- Cronk GA, Wheatley WB, Fellers GF, Albright H "The relationship of food intake to the absorption of potassium alpha-phenoxyethyl penicillin and potassium phenoxymethyl penicillin from the gastrointestinal tract." Am J Med Sci 240 (1960): 219-25
- Klein JO, Sabath LD, Finland M "Laboratory studies on oxacillin. I: in vitro activity against staphylococci and some other bacterial pathogens. II: absorption and urinary excretion in normal young." Am J Med Sci 245 (1963): 399-411
- Neuvonen PJ, Elonen E, Pentikainen PJ "Comparative effect of food on absorption of ampicillin and pivampicillin." J Int Med Res 5 (1977): 71-6
raNITIdine food
Applies to: ranitidine
H2 antagonists may reduce the clearance of nicotine. Cimetidine, 600 mg given twice a day for two days, reduced clearance of an intravenous nicotine dose by 30%. Ranitidine, 300 mg given twice a day for two days, reduced clearance by 10%. The clinical significance of this interaction is not known. Patients should be monitored for increased nicotine effects when using the patches or gum for smoking cessation and dosage adjustments should be made as appropriate.
References
- Bendayan R, Sullivan JT, Shaw C, Frecker RC, Sellers EM "Effect of cimetidine and ranitidine on the hepatic and renal elimination of nicotine in humans." Eur J Clin Pharmacol 38 (1990): 165-9
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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