Drug Interactions between Orkambi and Trikafta
This report displays the potential drug interactions for the following 2 drugs:
- Orkambi (ivacaftor/lumacaftor)
- Trikafta (elexacaftor/ivacaftor/tezacaftor)
Interactions between your drugs
No interactions were found between Orkambi and Trikafta. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Orkambi
A total of 534 drugs are known to interact with Orkambi.
- Orkambi is in the drug class CFTR combinations.
- Orkambi is used to treat Cystic Fibrosis.
Trikafta
A total of 439 drugs are known to interact with Trikafta.
- Trikafta is in the drug class CFTR combinations.
- Trikafta is used to treat Cystic Fibrosis.
Drug and food interactions
ivacaftor food
Applies to: Orkambi (ivacaftor / lumacaftor) and Trikafta (elexacaftor / ivacaftor / tezacaftor)
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of ivacaftor. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit. Elexacaftor and tezacaftor are also CYP450 3A4 substrates in vitro and may interact similarly with grapefruit juice, whereas lumacaftor is not expected to interact.
ADJUST DOSING INTERVAL: According to prescribing information, systemic exposure to ivacaftor increased approximately 2.5- to 4-fold, systemic exposure to elexacaftor increased approximately 1.9- to 2.5-fold, and systemic exposure to lumacaftor increased approximately 2-fold following administration with fat-containing foods relative to administration in a fasting state. Tezacaftor exposure is not significantly affected by administration of fat-containing foods.
MANAGEMENT: Patients treated with ivacaftor-containing medications should avoid consumption of grapefruit juice and any food that contains grapefruit or Seville oranges. All ivacaftor-containing medications should be administered with fat-containing foods such as eggs, avocados, nuts, meat, butter, peanut butter, cheese pizza, and whole-milk dairy products. A typical cystic fibrosis diet will satisfy this requirement.
References
- (2012) "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals
- (2015) "Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals
- (2022) "Product Information. Symdeko (ivacaftor-tezacaftor)." Vertex Pharmaceuticals
- (2019) "Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor)." Vertex Pharmaceuticals
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Cftr modulators
Therapeutic duplication
The recommended maximum number of medicines in the 'CFTR modulators' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'CFTR modulators' category:
- Orkambi (ivacaftor/lumacaftor)
- Trikafta (elexacaftor/ivacaftor/tezacaftor)
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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