Drug Interactions between Nexium and Renagel
This report displays the potential drug interactions for the following 2 drugs:
- Nexium (esomeprazole)
- Renagel (sevelamer)
Interactions between your drugs
No interactions were found between Nexium and Renagel. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Nexium
A total of 199 drugs are known to interact with Nexium.
- Nexium is in the drug class proton pump inhibitors.
- Nexium is used to treat the following conditions:
Renagel
A total of 43 drugs are known to interact with Renagel.
- Renagel is in the drug class phosphate binders.
- Renagel is used to treat Hyperphosphatemia of Renal Failure.
Drug and food interactions
sevelamer food
Applies to: Renagel (sevelamer)
ADJUST DOSING INTERVAL: Sevelamer may decrease the oral bioavailability of concomitantly administered drugs. While clinical data are lacking for most drugs, the intestinal absorption of some may be impaired due to sevelamer's binding capabilities.
MANAGEMENT: As a precaution, drugs that can be adversely affected by alterations in blood levels should be administered 1 hour before or 3 hours after sevelamer.
References
- "Product Information. Renagel (sevelamer)." Genzyme Corporation PROD (2001):
- "Product Information. Xatral (alfuzosin)." Sanofi-Synthelabo Canada Inc (2002):
esomeprazole food
Applies to: Nexium (esomeprazole)
ADJUST DOSING INTERVAL: Food may interfere with the absorption of esomeprazole. The manufacturer reports that the area under the concentration-time curve for esomeprazole following a single 40 mg dose was 33% to 53% lower when administered after food intake as opposed to during fasting conditions.
MANAGEMENT: Esomeprazole should be taken at least one hour before meals. When administered to patients receiving continuous enteral nutrition, some experts recommend that the tube feeding should be interrupted for at least 1 hour before and 1 hour after the dose of esomeprazole is given.
References
- "Product Information. Nexium (esomeprazole)." Astra-Zeneca Pharmaceuticals PROD (2001):
- Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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