Skip to main content

Drug Interactions between nelfinavir and Proleukin

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

aldesleukin nelfinavir

Applies to: Proleukin (aldesleukin) and nelfinavir

MONITOR: The use of aldesleukin may increase blood levels of some protease inhibitors by inhibiting their metabolism via the CYP450 3A4 pathway. Indinavir AUCs increased by 26% to 214% in 8 of 9 patients receiving concomitant therapy.

MANAGEMENT: Monitoring for signs and symptoms of protease inhibitor toxicity (e.g., hyperbilirubinemia, nausea, vomiting, diarrhea, flank pain, nephrolithiasis, urolithiasis) is recommended when aldesleukin is added or the dosage increased.

References

  1. Piscitelli SC, Vogel S, Figg WD, et al. (1998) "Alteration in indinavir clearance during interleukin-2 infusions in patients infected with the human immunodeficiency virus." Pharmacotherapy, 18, p. 1212-6

Switch to consumer interaction data

Drug and food interactions

No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer