Drug Interactions between MTE-6 and sarecycline
This report displays the potential drug interactions for the following 2 drugs:
- MTE-6 (trace elements with selenium and iodide)
- sarecycline
Interactions between your drugs
zinc sulfate sarecycline
Applies to: MTE-6 (trace elements with selenium and iodide) and sarecycline
ADJUST DOSING INTERVAL: The bioavailability of oral tetracyclines may be significantly decreased during concurrent administration with zinc-containing products. Therapeutic failure may result. The proposed mechanism is chelation of tetracyclines by the zinc cation, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. In seven healthy volunteers, simultaneous oral administration of zinc sulfate 200 mg and tetracycline 500 mg resulted in a 30% to 40% reduction in tetracycline serum concentrations compared to administration of tetracycline alone. In the same study, doxycycline absorption was not significantly affected by zinc coadministration. Other studies have reported reductions of greater than 50% in tetracycline absorption in the presence of zinc salts.
MANAGEMENT: Patients receiving an oral tetracycline in combination with zinc-containing products should be advised to separate the times of administration by at least three to four hours. Doxycycline may be an appropriate alternative, since its absorption may not be significantly affected by zinc coadministration.
References
- Neuvonen PJ (1976) "Interactions with the absorption of tetracyclines." Drugs, 11, p. 45-54
- Gothoni G, Neuvonen PJ, Mattila M, Hackman R (1972) "Iron-tetracycline interaction: effect of time interval between the drugs." Acta Med Scand, 191, p. 409-11
- Penttila O, Hurme H, Neuvonen PJ (1975) "Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man." Eur J Clin Pharmacol, 9, p. 131-4
- (2018) "Product Information. Seysara (sarecycline)." Allergan Inc
- (2018) "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc.
Drug and food interactions
No alcohol/food interactions were found. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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